Names & Taxonomy
- Uniprot ID:
- Q99705
- Entry Name:
- MCHR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein)
- Gene Names:
- MCHR1 GPR24 SLC1
- Gene Names Primary:
- MCHR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 422
- Sequence:
- MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
- Gene Ontology Go:
- integral component of plasma membrane
nonmotile primary cilium
plasma membrane
G-protein coupled receptor activity
melanin-concentrating hormone receptor activity
neuropeptide receptor activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cell surface receptor signaling pathway
feeding behavior
G-protein coupled receptor signaling pathway
generation of precursor metabolites and energy
positive regulation of cytosolic calcium ion concentration - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cell surface receptor signaling pathway
feeding behavior
generation of precursor metabolites and energy
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
melanin-concentrating hormone receptor activity
neuropeptide receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
nonmotile primary cilium
plasma membrane - Keywords:
- Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix