Names & Taxonomy
- Uniprot ID:
- Q99661
- Entry Name:
- KIF2C_HUMAN
- Status:
- reviewed
- Protein Names:
- Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK)
- Gene Names:
- KIF2C KNSL6
- Gene Names Primary:
- KIF2C
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 725
- Sequence:
- MAMDSSLQARLFPGLAIKIQRSNGLIHSANVRTVNLEKSCVSVEWAEGGATKGKEIDFDDVAAINPELLQLLPLHPKDNLPLQENVTIQKQKRRSVNSKIPAPKESLRSRSTRMSTVSELRITAQENDMEVELPAAANSRKQFSVPPAPTRPSCPAVAEIPLRMVSEEMEEQVHSIRGSSSANPVNSVRRKSCLVKEVEKMKNKREEKKAQNSEMRMKRAQEYDSSFPNWEFARMIKEFRATLECHPLTMTDPIEEHRICVCVRKRPLNKQELAKKEIDVISIPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKAQNASKGIYAMASRDVFLLKNQPCYRKLGLEVYVTFFEIYNGKLFDLLNKKAKLRVLEDGKQQVQVVGLQEHLVNSADDVIKMIDMGSACRTSGQTFANSNSSRSHACFQIILRAKGRMHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIATISPGISSCEYTLNTLRYADRVKELSPHSGPSGEQLIQMETEEMEACSNGALIPGNLSKEEEELSSQMSSFNEAMTQIRELEEKAMEELKEIIQQGPDWLELSEMTEQPDYDLETFVNKAESALAQQAKHFSALRDVIKALRLAMQLEEQASRQISSKKRPQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton
Function
- Function:
- In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.
- Gene Ontology Go:
- chromosome, centromeric region
condensed chromosome kinetochore
cytosol
kinesin complex
membrane
microtubule cytoskeleton
microtubule plus-end
nucleus
ATP binding
ATPase activity
centromeric DNA binding
microtubule motor activity
microtubule plus-end binding
antigen processing and presentation of exogenous peptide antigen via MHC class II
blood coagulation
cell division
cell proliferation
establishment or maintenance of microtubule cytoskeleton polarity
microtubule depolymerization
microtubule-based movement
mitotic cell cycle
mitotic metaphase plate congression
mitotic nuclear division
regulation of chromosome segregation
small GTPase mediated signal transduction - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class II
blood coagulation
cell division
cell proliferation
establishment or maintenance of microtubule cytoskeleton polarity
microtubule-based movement
microtubule depolymerization
mitotic cell cycle
mitotic metaphase plate congression
mitotic nuclear division
regulation of chromosome segregation
small GTPase mediated signal transduction - Gene Ontology Molecular Function:
- ATPase activity
ATP binding
centromeric DNA binding
microtubule motor activity
microtubule plus-end binding - Gene Ontology Cellular Component:
- chromosome, centromeric region
condensed chromosome kinetochore
cytosol
kinesin complex
membrane
microtubule cytoskeleton
microtubule plus-end
nucleus - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Cell cycle
Cell division
Centromere
Chromosome
Chromosome partition
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Kinetochore
Microtubule
Mitosis
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation - Interacts With:
- Q15691; Q5JR59