Names & Taxonomy
- Uniprot ID:
- Q99062
- Entry Name:
- CSF3R_HUMAN
- Status:
- reviewed
- Protein Names:
- Granulocyte colony-stimulating factor receptor (G-CSF receptor) (G-CSF-R) (CD antigen CD114)
- Gene Names:
- CSF3R GCSFR
- Gene Names Primary:
- CSF3R
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 836
- Sequence:
- MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWPSVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGLPTLVQTYVLQGDPRAVSTQPQSQSGTSDQVLYGQLLGSPTSPGPGHYLRCDSTQPLLAGLTPSPKSYENLWFQASPLGTLVTPAPSQEDDCVFGPLLNFPLLQGIRVHGMEALGSF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 2: Secreted
Function
- Function:
- Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.
- Cross Reference Drug Bank:
- DB00099 DB00019
- Gene Ontology Go:
- extracellular region
integral component of plasma membrane
cytokine receptor activity
receptor activity
amelogenesis
cell adhesion
defense response
neutrophil chemotaxis
regulation of myeloid cell differentiation
signal transduction - Gene Ontology Biological Process:
- amelogenesis
cell adhesion
defense response
neutrophil chemotaxis
regulation of myeloid cell differentiation
signal transduction - Gene Ontology Molecular Function:
- cytokine receptor activity
receptor activity - Gene Ontology Cellular Component:
- extracellular region
integral component of plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P40763; P0CG48