Names & Taxonomy

Uniprot ID:
Q96SW2
Entry Name:
CRBN_HUMAN
Status:
reviewed
Protein Names:
Protein cereblon
Gene Names:
CRBN AD-006
Gene Names Orf:
AD-006
Gene Names Primary:
CRBN
Organism:
Homo sapiens (Human)

Structure

Length:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.
Pathway:
Protein modification; protein ubiquitination.
Cross Reference Drug Bank:
DB00480 DB08910 DB01041
Gene Ontology Go:
Cul4A-RING E3 ubiquitin ligase complex
cytoplasm
membrane
nucleolus
nucleus
ATP-dependent peptidase activity
metal ion binding
negative regulation of ion transmembrane transport
negative regulation of protein homooligomerization
positive regulation of protein homodimerization activity
proteasome-mediated ubiquitin-dependent protein catabolic process
protein ubiquitination
Gene Ontology Biological Process:
negative regulation of ion transmembrane transport
negative regulation of protein homooligomerization
positive regulation of protein homodimerization activity
proteasome-mediated ubiquitin-dependent protein catabolic process
protein ubiquitination
Gene Ontology Molecular Function:
ATP-dependent peptidase activity
metal ion binding
Gene Ontology Cellular Component:
Cul4A-RING E3 ubiquitin ligase complex
cytoplasm
membrane
nucleolus
nucleus
Keywords:
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Membrane
Mental retardation
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation
Ubl conjugation pathway
Zinc
Interacts With:
Q8TB93; Q93062

Publication

PubMed ID:
14702039 16641997 15489334 10931946 17974005 15557513 17380424 18414909 20223979 24328678 25043012 25108355