Names & Taxonomy
- Uniprot ID:
- Q96RP9
- Entry Name:
- EFGM_HUMAN
- Status:
- reviewed
- Protein Names:
- Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1) (hEFG1)
- Gene Names:
- GFM1 EFG EFG1 GFM
- Gene Names Primary:
- GFM1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 751
- Sequence:
- MRLLGAAAVAALGRGRAPASLGWQRKQVNWKACRWSSSGVIPNEKIRNIGISAHIDSGKTTLTERVLYYTGRIAKMHEVKGKDGVGAVMDSMELERQRGITIQSAATYTMWKDVNINIIDTPGHVDFTIEVERALRVLDGAVLVLCAVGGVQCQTMTVNRQMKRYNVPFLTFINKLDRMGSNPARALQQMRSKLNHNAAFMQIPMGLEGNFKGIVDLIEERAIYFDGDFGQIVRYGEIPAELRAAATDHRQELIECVANSDEQLGEMFLEEKIPSISDLKLAIRRATLKRSFTPVFLGSALKNKGVQPLLDAVLEYLPNPSEVQNYAILNKEDDSKEKTKILMNSSRDNSHPFVGLAFKLEVGRFGQLTYVRSYQGELKKGDTIYNTRTRKKVRLQRLARMHADMMEDVEEVYAGDICALFGIDCASGDTFTDKANSGLSMESIHVPDPVISIAMKPSNKNDLEKFSKGIGRFTREDPTFKVYFDTENKETVISGMGELHLEIYAQRLEREYGCPCITGKPKVAFRETITAPVPFDFTHKKQSGGAGQYGKVIGVLEPLDPEDYTKLEFSDETFGSNIPKQFVPAVEKGFLDACEKGPLSGHKLSGLRFVLQDGAHHMVDSNEISFIRAGEGALKQALANATLCILEPIMAVEVVAPNEFQGQVIAGINRRHGVITGQDGVEDYFTLYADVPLNDMFGYSTELRSCTEGKGEYTMEYSRYQPCLPSTQEDVINKYLEATGQLPVKKGKAKN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
- Pathway:
- Protein biosynthesis; polypeptide chain elongation.
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
GTP binding
GTPase activity
poly(A) RNA binding
translation elongation factor activity
mitochondrial translation
mitochondrial translational elongation
organelle organization - Gene Ontology Biological Process:
- mitochondrial translation
mitochondrial translational elongation
organelle organization - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
poly(A) RNA binding
translation elongation factor activity - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Elongation factor
GTP-binding
Mitochondrion
Nucleotide-binding
Phosphoprotein
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide - Interacts With:
- Q969Q1