Names & Taxonomy
- Uniprot ID:
- Q96RN1
- Entry Name:
- S26A8_HUMAN
- Status:
- reviewed
- Protein Names:
- Testis anion transporter 1 (Anion exchange transporter) (Solute carrier family 26 member 8)
- Gene Names:
- SLC26A8 TAT1
- Gene Names Primary:
- SLC26A8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 970
- Sequence:
- MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSILVFLTVVVALRINKCIRISFNQYPIEFPMELFLIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPMDSYSPEGNSNEDV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.
- Enzyme Regulation:
- ENZYME REGULATION: Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters), gluconate, and by thiosulfate.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity
anion transmembrane transport
anion transport
bicarbonate transport
chloride transmembrane transport
chloride transport
meiotic cell cycle
multicellular organism development
oxalate transport
regulation of intracellular pH
regulation of membrane potential
sperm capacitation
sperm motility
sulfate transmembrane transport
sulfate transport - Gene Ontology Biological Process:
- anion transmembrane transport
anion transport
bicarbonate transport
chloride transmembrane transport
chloride transport
meiotic cell cycle
multicellular organism development
oxalate transport
regulation of intracellular pH
regulation of membrane potential
sperm capacitation
sperm motility
sulfate transmembrane transport
sulfate transport - Gene Ontology Molecular Function:
- anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Anion exchange
Complete proteome
Developmental protein
Differentiation
Glycoprotein
Ion transport
Meiosis
Membrane
Polymorphism
Reference proteome
Spermatogenesis
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P13569; Q9H0H5