Names & Taxonomy

Uniprot ID:
Q96RN1
Entry Name:
S26A8_HUMAN
Status:
reviewed
Protein Names:
Testis anion transporter 1 (Anion exchange transporter) (Solute carrier family 26 member 8)
Gene Names:
SLC26A8 TAT1
Gene Names Primary:
SLC26A8
Organism:
Homo sapiens (Human)

Structure

Length:
970
Sequence:
MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSILVFLTVVVALRINKCIRISFNQYPIEFPMELFLIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPMDSYSPEGNSNEDV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.
Enzyme Regulation:
ENZYME REGULATION: Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters), gluconate, and by thiosulfate.
Gene Ontology Go:
integral component of plasma membrane
plasma membrane
anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity
anion transmembrane transport
anion transport
bicarbonate transport
chloride transmembrane transport
chloride transport
meiotic cell cycle
multicellular organism development
oxalate transport
regulation of intracellular pH
regulation of membrane potential
sperm capacitation
sperm motility
sulfate transmembrane transport
sulfate transport
Gene Ontology Biological Process:
anion transmembrane transport
anion transport
bicarbonate transport
chloride transmembrane transport
chloride transport
meiotic cell cycle
multicellular organism development
oxalate transport
regulation of intracellular pH
regulation of membrane potential
sperm capacitation
sperm motility
sulfate transmembrane transport
sulfate transport
Gene Ontology Molecular Function:
anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity
Gene Ontology Cellular Component:
integral component of plasma membrane
plasma membrane
Keywords:
Alternative splicing
Anion exchange
Complete proteome
Developmental protein
Differentiation
Glycoprotein
Ion transport
Meiosis
Membrane
Polymorphism
Reference proteome
Spermatogenesis
Transmembrane
Transmembrane helix
Transport
Interacts With:
P13569; Q9H0H5

Publication

PubMed ID:
11278976 11834742 14574404 15489334 14702039 22121115 15579655 17517695 23582645