Names & Taxonomy
- Uniprot ID:
- Q96PE3
- Entry Name:
- INP4A_HUMAN
- Status:
- reviewed
- Protein Names:
- Type I inositol 3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type I)
- Gene Names:
- INPP4A
- Gene Names Primary:
- INPP4A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 977
- Sequence:
- MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKGNPDSHAYWIRPEDPFCDVPSSPCPSTMPSTACHPHLTTHCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate.
- Pathway:
- Signal transduction; phosphatidylinositol signaling pathway.
- Catalytic Activity:
- 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
- Gene Ontology Go:
- cytosol
phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
inositol phosphate metabolic process
phosphatidylinositol biosynthetic process
phospholipid metabolic process
signal transduction
small molecule metabolic process - Gene Ontology Biological Process:
- inositol phosphate metabolic process
phosphatidylinositol biosynthetic process
phospholipid metabolic process
signal transduction
small molecule metabolic process - Gene Ontology Molecular Function:
- phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- Alternative splicing
Complete proteome
Hydrolase
Phosphoprotein
Polymorphism
Reference proteome