Names & Taxonomy
- Uniprot ID:
- Q96N76
- Entry Name:
- HUTU_HUMAN
- Status:
- reviewed
- Protein Names:
- Urocanate hydratase (Urocanase) (EC 4.2.1.49) (Imidazolonepropionate hydrolase)
- Gene Names:
- UROC1
- Gene Names Primary:
- UROC1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 676
- Sequence:
- MSSLQALCSGLPLRPLPENRGRQAGVPHAPVRTPSLSPVEKQLALRNALRYFPPDVQELLAPEFAQELQLYGHIYMYRFCPDIEMRAYPIEQYPCQTKVAAAIMHMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLTMFYLSKMTEEQTLVMYSGHPLGLFPSSRSAPRLVITNGMVIPNYSSRTEYEKLFALGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAARRYLGIEDLAGKVFVTSGLGGMSGAQAKAAVIVGCIGVIAEVDKAALEKRHRQGWLMEVTDSLDRCIQRLREARKKKEVLSLGYHGNVVALWERLVHELDTTGECLVDLGSDQTSCHNPFNGGYYPVQLSFTEAQSLMASNPAVFKDLVQESLRRQVSAINRLAEEKFFFWDYGNAFLLEAQRAGADVEKKGAGRTEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDELATSVLEEAIADGVKVSVKLQYMDNIRWIREAARHRLVVGSQARILYSDQKGRVAIAVAINQAIACRRIKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDACRGATWVALHNGGGVGWGEVINGGFGLVLDGTPEAEGRARLMLSWDVSNGVARRCWSGNQKAYEIICQTMQENSTLVVTLPHKVEDERVLQQALQL
- Proteomes:
- UP000005640
Function
- Pathway:
- Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.
- Catalytic Activity:
- 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H(2)O.
- Cofactor:
- COFACTOR: Name=NAD(+); Xref=ChEBI:CHEBI:57540;
- Gene Ontology Go:
- cytosol
urocanate hydratase activity
cellular nitrogen compound metabolic process
histidine catabolic process
histidine catabolic process to glutamate and formamide
histidine catabolic process to glutamate and formate
small molecule metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
histidine catabolic process
histidine catabolic process to glutamate and formamide
histidine catabolic process to glutamate and formate
small molecule metabolic process - Gene Ontology Molecular Function:
- urocanate hydratase activity
- Gene Ontology Cellular Component:
- cytosol
- Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Histidine metabolism
Lyase
NAD
Polymorphism
Reference proteome