Names & Taxonomy
- Uniprot ID:
- Q96LI5
- Entry Name:
- CNO6L_HUMAN
- Status:
- reviewed
- Protein Names:
- CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4) (Carbon catabolite repressor protein 4 homolog B)
- Gene Names:
- CNOT6L CCR4B
- Gene Names Primary:
- CNOT6L
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 555
- Sequence:
- MRLIGMPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLAVHPEQLPPRPWITLKERDQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQEVETEQYFTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGAGMKPIHAADKQLLIVANAHMHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRYNECLMNFSCNGKNGSSEGRITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLELHPPLLPLVNGVHLPNRR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus.
Function
- Function:
- Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.
- Catalytic Activity:
- Exonucleolytic cleavage of poly(A) to 5'-AMP.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 240 240
- Gene Ontology Go:
- CCR4-NOT complex
cytoplasm
cytosol
nucleus
metal ion binding
poly(A)-specific ribonuclease activity
gene expression
gene silencing by RNA
mRNA destabilization
mRNA processing
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of cell proliferation
positive regulation of cytoplasmic mRNA processing body assembly
regulation of transcription, DNA-templated
transcription, DNA-templated - Gene Ontology Biological Process:
- gene expression
gene silencing by RNA
mRNA destabilization
mRNA processing
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of cell proliferation
positive regulation of cytoplasmic mRNA processing body assembly
regulation of transcription, DNA-templated
transcription, DNA-templated - Gene Ontology Molecular Function:
- metal ion binding
poly(A)-specific ribonuclease activity - Gene Ontology Cellular Component:
- CCR4-NOT complex
cytoplasm
cytosol
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Exonuclease
Hydrolase
Leucine-rich repeat
Magnesium
Metal-binding
Nuclease
Nucleus
RNA-mediated gene silencing
Reference proteome
Repeat
Transcription
Transcription regulation
Translation regulation
mRNA processing - Interacts With:
- A5YKK6; Q9NZN8; O75175; P50616