Names & Taxonomy

Uniprot ID:
Q96LI5
Entry Name:
CNO6L_HUMAN
Status:
reviewed
Protein Names:
CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4) (Carbon catabolite repressor protein 4 homolog B)
Gene Names:
CNOT6L CCR4B
Gene Names Primary:
CNOT6L
Organism:
Homo sapiens (Human)

Structure

Length:
555
Sequence:
MRLIGMPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLAVHPEQLPPRPWITLKERDQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQEVETEQYFTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGAGMKPIHAADKQLLIVANAHMHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRYNECLMNFSCNGKNGSSEGRITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLELHPPLLPLVNGVHLPNRR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm. Nucleus.

Function

Function:
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.
Catalytic Activity:
Exonucleolytic cleavage of poly(A) to 5'-AMP.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Active Site:
ACT_SITE 240 240
Gene Ontology Go:
CCR4-NOT complex
cytoplasm
cytosol
nucleus
metal ion binding
poly(A)-specific ribonuclease activity
gene expression
gene silencing by RNA
mRNA destabilization
mRNA processing
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of cell proliferation
positive regulation of cytoplasmic mRNA processing body assembly
regulation of transcription, DNA-templated
transcription, DNA-templated
Gene Ontology Biological Process:
gene expression
gene silencing by RNA
mRNA destabilization
mRNA processing
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of cell proliferation
positive regulation of cytoplasmic mRNA processing body assembly
regulation of transcription, DNA-templated
transcription, DNA-templated
Gene Ontology Molecular Function:
metal ion binding
poly(A)-specific ribonuclease activity
Gene Ontology Cellular Component:
CCR4-NOT complex
cytoplasm
cytosol
nucleus
Keywords:
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Exonuclease
Hydrolase
Leucine-rich repeat
Magnesium
Metal-binding
Nuclease
Nucleus
RNA-mediated gene silencing
Reference proteome
Repeat
Transcription
Transcription regulation
Translation regulation
mRNA processing
Interacts With:
A5YKK6; Q9NZN8; O75175; P50616

Publication

PubMed ID:
14702039 15815621 17974005 17452450 18377426 19558367 21269460 21233283 20628353