Names & Taxonomy
- Uniprot ID:
- Q96JJ6
- Entry Name:
- JPH4_HUMAN
- Status:
- reviewed
- Protein Names:
- Junctophilin-4 (JP-4) (Junctophilin-like 1 protein)
- Gene Names:
- JPH4 JPHL1 KIAA1831
- Gene Names Primary:
- JPH4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 628
- Sequence:
- MSPGGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRTSLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGPGDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRRSSLGSKRGSLRSEVSSEVGSTGPPGSEASGPPAAAPPALIEGSATEVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARRAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDSEGSDTEPLDEDSPGVYENGLTPSEGSPELPSSPASSRQPWRPPACRSPLPPGGDQGPFSSPKAWPEEWGGAGAQAEELAGYEAEDEAGMQGPGPRDGSPLLGGCSDSSGSLREEEGEDEEPLPPLRAPAGTEPEPIAMLVLRGSSSRGPDAGCLTEELGEPAATERPAQPGAANPLVVGAVALLDLSLAFLFSQLLT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity).
- Gene Ontology Go:
- dendritic shaft
integral component of membrane
junctional sarcoplasmic reticulum membrane
plasma membrane
smooth endoplasmic reticulum
calcium ion transport into cytosol
learning
neuromuscular process controlling balance
regulation of ryanodine-sensitive calcium-release channel activity
regulation of synaptic plasticity - Gene Ontology Biological Process:
- calcium ion transport into cytosol
learning
neuromuscular process controlling balance
regulation of ryanodine-sensitive calcium-release channel activity
regulation of synaptic plasticity - Gene Ontology Cellular Component:
- dendritic shaft
integral component of membrane
junctional sarcoplasmic reticulum membrane
plasma membrane
smooth endoplasmic reticulum - Keywords:
- Cell membrane
Complete proteome
Endoplasmic reticulum
Membrane
Reference proteome
Repeat
Transmembrane
Transmembrane helix