Names & Taxonomy
- Uniprot ID:
- Q96J84
- Entry Name:
- KIRR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1)
- Gene Names:
- KIRREL KIRREL1 NEPH1
- Gene Names Primary:
- KIRREL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 757
- Sequence:
- MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).
- Gene Ontology Go:
- cell projection membrane
cell-cell junction
dendritic shaft
extracellular exosome
integral component of membrane
membrane raft
perinuclear region of cytoplasm
plasma membrane
myosin binding
excretion
negative regulation of protein phosphorylation
positive regulation of actin filament polymerization
single organismal cell-cell adhesion - Gene Ontology Biological Process:
- excretion
negative regulation of protein phosphorylation
positive regulation of actin filament polymerization
single organismal cell-cell adhesion - Gene Ontology Molecular Function:
- myosin binding
- Gene Ontology Cellular Component:
- cell-cell junction
cell projection membrane
dendritic shaft
extracellular exosome
integral component of membrane
membrane raft
perinuclear region of cytoplasm
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Q07157