Names & Taxonomy

Uniprot ID:
Q96J84
Entry Name:
KIRR1_HUMAN
Status:
reviewed
Protein Names:
Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1)
Gene Names:
KIRREL KIRREL1 NEPH1
Gene Names Primary:
KIRREL
Organism:
Homo sapiens (Human)

Structure

Length:
757
Sequence:
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).
Gene Ontology Go:
cell projection membrane
cell-cell junction
dendritic shaft
extracellular exosome
integral component of membrane
membrane raft
perinuclear region of cytoplasm
plasma membrane
myosin binding
excretion
negative regulation of protein phosphorylation
positive regulation of actin filament polymerization
single organismal cell-cell adhesion
Gene Ontology Biological Process:
excretion
negative regulation of protein phosphorylation
positive regulation of actin filament polymerization
single organismal cell-cell adhesion
Gene Ontology Molecular Function:
myosin binding
Gene Ontology Cellular Component:
cell-cell junction
cell projection membrane
dendritic shaft
extracellular exosome
integral component of membrane
membrane raft
perinuclear region of cytoplasm
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Interacts With:
Q07157

Publication

PubMed ID:
11416156 16710414 15489334 14702039 15144186 19159218 19690332