Names & Taxonomy
- Uniprot ID:
- Q96I59
- Entry Name:
- SYNM_HUMAN
- Status:
- reviewed
- Protein Names:
- Probable asparagine--tRNA ligase, mitochondrial (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS)
- Gene Names:
- NARS2
- Gene Names Primary:
- NARS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 477
- Sequence:
- MLGVRCLLRSVRFCSSAPFPKHKPSAKLSVRDALGAQNASGERIKIQGWIRSVRSQKEVLFLHVNDGSSLESLQVVADSGLDSRELNFGSSVEVQGQLIKSPSKRQNVELKAEKIKVIGNCDAKDFPIKYKERHPLEYLRQYPHFRCRTNVLGSILRIRSEATAAIHSFFKDSGFVHIHTPIITSNDSEGAGELFQLEPSGKLKVPEENFFNVPAFLTVSGQLHLEVMSGAFTQVFTFGPTFRAENSQSRRHLAEFYMIEAEISFVDSLQDLMQVIEELFKATTMMVLSKCPEDVELCHKFIAPGQKDRLEHMLKNNFLIISYTEAVEILKQASQNFTFTPEWGADLRTEHEKYLVKHCGNIPVFVINYPLTLKPFYMRDNEDGPQHTVAAVDLLVPGVGELFGGGLREERYHFLEERLARSGLTEVYQWYLDLRRFGSVPHGGFGMGFERYLQCILGVDNIKDVIPFPRFPHSCLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Catalytic Activity:
- ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).
- Cross Reference Drug Bank:
- DB00174
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
asparagine-tRNA ligase activity
ATP binding
nucleic acid binding
asparaginyl-tRNA aminoacylation
gene expression
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- asparaginyl-tRNA aminoacylation
gene expression
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- asparagine-tRNA ligase activity
ATP binding
nucleic acid binding - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
Complete proteome
Deafness
Disease mutation
Leigh syndrome
Ligase
Mitochondrion
Non-syndromic deafness
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide