Names & Taxonomy
- Uniprot ID:
- Q96GR2
- Entry Name:
- ACBG1_HUMAN
- Status:
- reviewed
- Protein Names:
- Long-chain-fatty-acid--CoA ligase ACSBG1 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 1) (hBG1) (hsBG) (hsBGM) (Lipidosin)
- Gene Names:
- ACSBG1 BGM KIAA0631 LPD
- Gene Names Primary:
- ACSBG1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 724
- Sequence:
- MPRNSGAGYGCPHGDPSMLDSRETPQESRQDMIVRTTQEKLKTSSLTDRQPLSKESLNHALELSVPEKVNNAQWDAPEEALWTTRADGRVRLRIDPSCPQLPYTVHRMFYEALDKYGDLIALGFKRQDKWEHISYSQYYLLARRAAKGFLKLGLKQAHSVAILGFNSPEWFFSAVGTVFAGGIVTGIYTTSSPEACQYIAYDCCANVIMVDTQKQLEKILKIWKQLPHLKAVVIYKEPPPNKMANVYTMEEFMELGNEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNITWTARYGSQAGDIRPAEVQQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFAEPDALKGSLVNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPGSDLKPFTTRLADYLVLAKVRQALGFAKCQKNFYGAAPMMAETQHFFLGLNIRLYAGYGLSETSGPHFMSSPYNYRLYSSGKLVPGCRVKLVNQDAEGIGEICLWGRTIFMGYLNMEDKTCEAIDEEGWLHTGDAGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLIGDQRKFLSMLLTLKCTLDPDTSDQTDNLTEQAMEFCQRVGSRATTVSEIIEKKDEAVYQAIEEGIRRVNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIIDSFYQEQKM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.
- Catalytic Activity:
- ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
- Gene Ontology Go:
- cytoplasm
cytoplasmic, membrane-bounded vesicle
cytosol
endoplasmic reticulum
ATP binding
long-chain fatty acid-CoA ligase activity
very long-chain fatty acid-CoA ligase activity
cellular lipid metabolic process
long-chain fatty acid metabolic process
long-chain fatty-acyl-CoA biosynthetic process
myelination
ovarian follicle atresia
response to glucocorticoid
small molecule metabolic process
triglyceride biosynthetic process
very long-chain fatty acid metabolic process - Gene Ontology Biological Process:
- cellular lipid metabolic process
long-chain fatty acid metabolic process
long-chain fatty-acyl-CoA biosynthetic process
myelination
ovarian follicle atresia
response to glucocorticoid
small molecule metabolic process
triglyceride biosynthetic process
very long-chain fatty acid metabolic process - Gene Ontology Molecular Function:
- ATP binding
long-chain fatty acid-CoA ligase activity
very long-chain fatty acid-CoA ligase activity - Gene Ontology Cellular Component:
- cytoplasm
cytoplasmic, membrane-bounded vesicle
cytosol
endoplasmic reticulum - Keywords:
- ATP-binding
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum
Fatty acid metabolism
Ligase
Lipid metabolism
Microsome
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome