Names & Taxonomy
- Uniprot ID:
- Q96G23
- Entry Name:
- CERS2_HUMAN
- Status:
- reviewed
- Protein Names:
- Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Tumor metastasis-suppressor gene 1 protein)
- Gene Names:
- CERS2 LASS2 TMSG1
- Gene Names Primary:
- CERS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 380
- Sequence:
- MLQTLYDYFWWERLWLPVNLTWADLEDRDGRVYAKASDLYITLPLALLFLIVRYFFELYVATPLAALLNIKEKTRLRAPPNATLEHFYLTSGKQPKQVEVELLSRQSGLSGRQVERWFRRRRNQDRPSLLKKFREASWRFTFYLIAFIAGMAVIVDKPWFYDMKKVWEGYPIQSTIPSQYWYYMIELSFYWSLLFSIASDVKRKDFKEQIIHHVATIILISFSWFANYIRAGTLIMALHDSSDYLLESAKMFNYAGWKNTCNNIFIVFAIVFIITRLVILPFWILHCTLVYPLELYPAFFGYYFFNSMMGVLQLLHIFWAYLILRMAHKFITGKLVEDERSDREETESSEGEEAAAGGGAKSRPLANGHPILNNNHRKND
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus membrane
Function
- Function:
- Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
membrane
nuclear membrane
DNA binding
sphingosine N-acyltransferase activity
ceramide biosynthetic process
negative regulation of axon regeneration
negative regulation of Schwann cell migration
negative regulation of Schwann cell proliferation involved in axon regeneration
small molecule metabolic process
sphingolipid biosynthetic process
sphingolipid metabolic process - Gene Ontology Biological Process:
- ceramide biosynthetic process
negative regulation of axon regeneration
negative regulation of Schwann cell migration
negative regulation of Schwann cell proliferation involved in axon regeneration
small molecule metabolic process
sphingolipid biosynthetic process
sphingolipid metabolic process - Gene Ontology Molecular Function:
- DNA binding
sphingosine N-acyltransferase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
membrane
nuclear membrane - Keywords:
- Complete proteome
DNA-binding
Endoplasmic reticulum
Glycoprotein
Homeobox
Lipid biosynthesis
Lipid metabolism
Membrane
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix - Interacts With:
- P07306; P07307; P27449; P07900; O15245