Names & Taxonomy
- Uniprot ID:
- Q96F10
- Entry Name:
- SAT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Diamine acetyltransferase 2 (EC 2.3.1.57) (Polyamine N-acetyltransferase 2) (Spermidine/spermine N(1)-acetyltransferase 2) (Thialysine N-epsilon-acetyltransferase)
- Gene Names:
- SAT2 SSAT2
- Gene Names Primary:
- SAT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 170
- Sequence:
- MASVRIREAKEGDCGDILRLIRELAEFEKLSDQVKISEEALRADGFGDNPFYHCLVAEILPAPGKLLGPCVVGYGIYYFIYSTWKGRTIYLEDIYVMPEYRGQGIGSKIIKKVAEVALDKGCSQFRLAVLDWNQRAMDLYKALGAQDLTEAEGWHFFCFQGEATRKLAGK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Note=Intracellular organelles.
Function
- Function:
- Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine.
- Pathway:
- Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1.
- Catalytic Activity:
- Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.
- Cross Reference Drug Bank:
- DB00127
- Gene Ontology Go:
- cytoplasm
extracellular exosome
diamine N-acetyltransferase activity
nor-spermidine metabolic process
putrescine acetylation
putrescine catabolic process
spermidine acetylation
spermine acetylation - Gene Ontology Biological Process:
- nor-spermidine metabolic process
putrescine acetylation
putrescine catabolic process
spermidine acetylation
spermine acetylation - Gene Ontology Molecular Function:
- diamine N-acetyltransferase activity
- Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Acyltransferase
Complete proteome
Cytoplasm
Polymorphism
Reference proteome
Transferase