Names & Taxonomy

Uniprot ID:
Q96F10
Entry Name:
SAT2_HUMAN
Status:
reviewed
Protein Names:
Diamine acetyltransferase 2 (EC 2.3.1.57) (Polyamine N-acetyltransferase 2) (Spermidine/spermine N(1)-acetyltransferase 2) (Thialysine N-epsilon-acetyltransferase)
Gene Names:
SAT2 SSAT2
Gene Names Primary:
SAT2
Organism:
Homo sapiens (Human)

Structure

Length:
170
Sequence:
MASVRIREAKEGDCGDILRLIRELAEFEKLSDQVKISEEALRADGFGDNPFYHCLVAEILPAPGKLLGPCVVGYGIYYFIYSTWKGRTIYLEDIYVMPEYRGQGIGSKIIKKVAEVALDKGCSQFRLAVLDWNQRAMDLYKALGAQDLTEAEGWHFFCFQGEATRKLAGK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm. Note=Intracellular organelles.

Function

Function:
Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine.
Pathway:
Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1.
Catalytic Activity:
Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.
Cross Reference Drug Bank:
DB00127
Gene Ontology Go:
cytoplasm
extracellular exosome
diamine N-acetyltransferase activity
nor-spermidine metabolic process
putrescine acetylation
putrescine catabolic process
spermidine acetylation
spermine acetylation
Gene Ontology Biological Process:
nor-spermidine metabolic process
putrescine acetylation
putrescine catabolic process
spermidine acetylation
spermine acetylation
Gene Ontology Molecular Function:
diamine N-acetyltransferase activity
Gene Ontology Cellular Component:
cytoplasm
extracellular exosome
Keywords:
3D-structure
Acetylation
Acyltransferase
Complete proteome
Cytoplasm
Polymorphism
Reference proteome
Transferase

Publication

PubMed ID:
15489334 12803540 19608861 24275569 16596569