Names & Taxonomy
- Uniprot ID:
- Q96A70
- Entry Name:
- AZIN2_HUMAN
- Status:
- reviewed
- Protein Names:
- Antizyme inhibitor 2 (AzI2) (Arginine decarboxylase) (ADC) (ARGDC) (Ornithine decarboxylase-like protein) (ODC-like protein) (ornithine decarboxylase paralog) (ODC-p)
- Gene Names:
- AZIN2 ADC KIAA1945 ODCP
- Gene Names Primary:
- AZIN2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 460
- Sequence:
- MAGYLSESDFVMVEEGFSTRDLLKELTLGASQATTDEVAAFFVADLGAIVRKHFCFLKCLPRVRPFYAVKCNSSPGVLKVLAQLGLGFSCANKAEMELVQHIGIPASKIICANPCKQIAQIKYAAKHGIQLLSFDNEMELAKVVKSHPSAKMVLCIATDDSHSLSCLSLKFGVSLKSCRHLLENAKKHHVEVVGVSFHIGSGCPDPQAYAQSIADARLVFEMGTELGHKMHVLDLGGGFPGTEGAKVRFEEIASVINSALDLYFPEGCGVDIFAELGRYYVTSAFTVAVSIIAKKEVLLDQPGREEENGSTSKTIVYHLDEGVYGIFNSVLFDNICPTPILQKKPSTEQPLYSSSLWGPAVDGCDCVAEGLWLPQLHVGDWLVFDNMGAYTVGMGSPFWGTQACHITYAMSRVAWEALRRQLMAAEQEDDVEGVCKPLSCGWEITDTLCVGPVFTPASIM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Cytoplasm
Function
- Function:
- Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizymes OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC1 degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).
- Cross Reference Drug Bank:
- DB00125
- Gene Ontology Go:
- axon
cis-Golgi network
cytoplasmic vesicle
cytosol
dendrite
endoplasmic reticulum-Golgi intermediate compartment membrane
granular vesicle
mitochondrion
nucleus
perikaryon
perinuclear region of cytoplasm
trans-Golgi network
transport vesicle
catalytic activity
ornithine decarboxylase activator activity
putrescine transmembrane transporter activity
agmatine biosynthetic process
cellular nitrogen compound metabolic process
negative regulation of protein catabolic process
polyamine metabolic process
positive regulation of catalytic activity
positive regulation of polyamine transmembrane transport
putrescine biosynthetic process from ornithine
putrescine transport
small molecule metabolic process
spermatogenesis
trans-Golgi network membrane organization - Gene Ontology Biological Process:
- agmatine biosynthetic process
cellular nitrogen compound metabolic process
negative regulation of protein catabolic process
polyamine metabolic process
positive regulation of catalytic activity
positive regulation of polyamine transmembrane transport
putrescine biosynthetic process from ornithine
putrescine transport
small molecule metabolic process
spermatogenesis
trans-Golgi network membrane organization - Gene Ontology Molecular Function:
- catalytic activity
ornithine decarboxylase activator activity
putrescine transmembrane transporter activity - Gene Ontology Cellular Component:
- axon
cis-Golgi network
cytoplasmic vesicle
cytosol
dendrite
endoplasmic reticulum-Golgi intermediate compartment membrane
granular vesicle
mitochondrion
nucleus
perikaryon
perinuclear region of cytoplasm
trans-Golgi network
transport vesicle - Keywords:
- Alternative splicing
Cell projection
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Golgi apparatus
Membrane
Nucleus
Polyamine biosynthesis
Polymorphism
Pyridoxal phosphate
Reference proteome
Transport
Ubl conjugation - Interacts With:
- Q9UMX2