Names & Taxonomy
- Uniprot ID:
- Q969X1
- Entry Name:
- LFG3_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein lifeguard 3 (Protein RECS1 homolog) (Transmembrane BAX inhibitor motif-containing protein 1)
- Gene Names:
- TMBIM1 LFG3 RECS1 PP1201 PSEC0158
- Gene Names Orf:
- PP1201 PSEC0158
- Gene Names Primary:
- TMBIM1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 311
- Sequence:
- MSNPSAPPPYEDRNPLYPGPPPPGGYGQPSVLPGGYPAYPGYPQPGYGHPAGYPQPMPPTHPMPMNYGPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.
- Gene Ontology Go:
- endosome membrane
extracellular exosome
Golgi apparatus
integral component of membrane
lysosomal membrane
death receptor binding
negative regulation of establishment of protein localization to plasma membrane
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of Fas signaling pathway
negative regulation of metalloenzyme activity
positive regulation of blood vessel remodeling - Gene Ontology Biological Process:
- negative regulation of establishment of protein localization to plasma membrane
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of Fas signaling pathway
negative regulation of metalloenzyme activity
positive regulation of blood vessel remodeling - Gene Ontology Molecular Function:
- death receptor binding
- Gene Ontology Cellular Component:
- endosome membrane
extracellular exosome
Golgi apparatus
integral component of membrane
lysosomal membrane - Keywords:
- Complete proteome
Endosome
Lysosome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix