Names & Taxonomy

Uniprot ID:
Q969X1
Entry Name:
LFG3_HUMAN
Status:
reviewed
Protein Names:
Protein lifeguard 3 (Protein RECS1 homolog) (Transmembrane BAX inhibitor motif-containing protein 1)
Gene Names:
TMBIM1 LFG3 RECS1 PP1201 PSEC0158
Gene Names Orf:
PP1201 PSEC0158
Gene Names Primary:
TMBIM1
Organism:
Homo sapiens (Human)

Structure

Length:
311
Sequence:
MSNPSAPPPYEDRNPLYPGPPPPGGYGQPSVLPGGYPAYPGYPQPGYGHPAGYPQPMPPTHPMPMNYGPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.
Gene Ontology Go:
endosome membrane
extracellular exosome
Golgi apparatus
integral component of membrane
lysosomal membrane
death receptor binding
negative regulation of establishment of protein localization to plasma membrane
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of Fas signaling pathway
negative regulation of metalloenzyme activity
positive regulation of blood vessel remodeling
Gene Ontology Biological Process:
negative regulation of establishment of protein localization to plasma membrane
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of Fas signaling pathway
negative regulation of metalloenzyme activity
positive regulation of blood vessel remodeling
Gene Ontology Molecular Function:
death receptor binding
Gene Ontology Cellular Component:
endosome membrane
extracellular exosome
Golgi apparatus
integral component of membrane
lysosomal membrane
Keywords:
Complete proteome
Endosome
Lysosome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

Publication

PubMed ID:
14702039 15498874 16303743 15489334 16607040 18088087 19784873