Names & Taxonomy
- Uniprot ID:
- Q92824
- Entry Name:
- PCSK5_HUMAN
- Status:
- reviewed
- Protein Names:
- Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5)
- Gene Names:
- PCSK5 PC5 PC6
- Gene Names Primary:
- PCSK5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1860
- Sequence:
- MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDGEYVDEHGHCQTCEASCAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTSCGADNYGREHFLYQGECGDSCPEGHYATEGNTCLPCPDNCELCHSVHVCTRCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYRFDHHCYKTCPEKTYSEEVECKACDSNCGSCDQNGCYWCEEGFFLLGGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKETKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECCDCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAGYEKLADPNKSYSSYKSSYRESTSFEEDQVIEYRDRDYDEDDDDDIVYMGQDGTVYRKFKYGLLDDDDIDELEYDDESYSYYQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform PC6A: Secreted. Note=Secreted through the regulated secretory pathway.
Function
- Function:
- Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.
- Catalytic Activity:
- Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.
- Active Site:
- ACT_SITE 171 171 Charge relay system.
- Gene Ontology Go:
- extracellular space
Golgi apparatus
Golgi lumen
integral component of membrane
secretory granule
peptidase activity
peptide binding
serine-type endopeptidase activity
anterior/posterior pattern specification
cardiac septum development
cell-cell signaling
coronary vasculature development
cytokine biosynthetic process
determination of left/right symmetry
embryo implantation
embryonic digestive tract development
embryonic skeletal system development
heart development
kidney development
limb morphogenesis
nerve growth factor processing
neurotrophin TRK receptor signaling pathway
peptide biosynthetic process
peptide hormone processing
protein processing
renin secretion into blood stream
respiratory tube development
signal peptide processing
viral life cycle - Gene Ontology Biological Process:
- anterior/posterior pattern specification
cardiac septum development
cell-cell signaling
coronary vasculature development
cytokine biosynthetic process
determination of left/right symmetry
embryo implantation
embryonic digestive tract development
embryonic skeletal system development
heart development
kidney development
limb morphogenesis
nerve growth factor processing
neurotrophin TRK receptor signaling pathway
peptide biosynthetic process
peptide hormone processing
protein processing
renin secretion into blood stream
respiratory tube development
signal peptide processing
viral life cycle - Gene Ontology Molecular Function:
- peptidase activity
peptide binding
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- extracellular space
Golgi apparatus
Golgi lumen
integral component of membrane
secretory granule - Keywords:
- Alternative splicing
Cleavage on pair of basic residues
Complete proteome
Glycoprotein
Hydrolase
Membrane
Pregnancy
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal
Transmembrane
Transmembrane helix
Zymogen - Interacts With:
- O76003; P60409; P60410; Q9BQ66; P26371; Q5T5A8; A4D127; Q7Z3S9; A1L3A7; O75716