Names & Taxonomy
- Uniprot ID:
- Q92806
- Entry Name:
- KCNJ9_HUMAN
- Status:
- reviewed
- Protein Names:
- G protein-activated inward rectifier potassium channel 3 (GIRK-3) (Inward rectifier K(+) channel Kir3.3) (Potassium channel, inwardly rectifying subfamily J member 9)
- Gene Names:
- KCNJ9 GIRK3
- Gene Names Primary:
- KCNJ9
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 393
- Sequence:
- MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDAHLYWSIPSRLDEKVEEEGAGEGAGGEAGADKEQNGCLPPPESESKV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
- Intramembrane:
- INTRAMEM 107 118 Helical; Pore-forming; Name=H5.
Function
- Function:
- This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).
- Cross Reference Drug Bank:
- DB00898
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
G-protein activated inward rectifier potassium channel activity
inward rectifier potassium channel activity
potassium ion import
synaptic transmission - Gene Ontology Biological Process:
- potassium ion import
synaptic transmission - Gene Ontology Molecular Function:
- G-protein activated inward rectifier potassium channel activity
inward rectifier potassium channel activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Complete proteome
Ion channel
Ion transport
Membrane
Polymorphism
Potassium
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel