Names & Taxonomy
- Uniprot ID:
- Q92753
- Entry Name:
- RORB_HUMAN
- Status:
- reviewed
- Protein Names:
- Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta)
- Gene Names:
- RORB NR1F2 RZRB
- Gene Names Primary:
- RORB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 470
- Sequence:
- MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).
- Cross Reference Drug Bank:
- DB01065
- Gene Ontology Go:
- nucleoplasm
nucleus
melatonin receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
sequence-specific DNA binding
steroid hormone receptor activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding
amacrine cell differentiation
brain development
cellular response to retinoic acid
circadian rhythm
eye photoreceptor cell development
gene expression
intracellular receptor signaling pathway
negative regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
regulation of circadian rhythm
regulation of transcription, DNA-templated
retina development in camera-type eye
retinal cone cell development
retinal rod cell development
transcription initiation from RNA polymerase II promoter
visual perception - Gene Ontology Biological Process:
- amacrine cell differentiation
brain development
cellular response to retinoic acid
circadian rhythm
eye photoreceptor cell development
gene expression
intracellular receptor signaling pathway
negative regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
regulation of circadian rhythm
regulation of transcription, DNA-templated
retina development in camera-type eye
retinal cone cell development
retinal rod cell development
transcription initiation from RNA polymerase II promoter
visual perception - Gene Ontology Molecular Function:
- melatonin receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
sequence-specific DNA binding
steroid hormone receptor activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- nucleoplasm
nucleus - Keywords:
- Activator
Alternative promoter usage
Biological rhythms
Complete proteome
DNA-binding
Developmental protein
Metal-binding
Nucleus
Receptor
Reference proteome
Sensory transduction
Transcription
Transcription regulation
Vision
Zinc
Zinc-finger - Interacts With:
- O08785