Names & Taxonomy
- Uniprot ID:
- Q92752
- Entry Name:
- TENR_HUMAN
- Status:
- reviewed
- Protein Names:
- Tenascin-R (TN-R) (Janusin) (Restrictin)
- Gene Names:
- TNR
- Gene Names Primary:
- TNR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1358
- Sequence:
- MGADGETVVLKNMLIGINLILLGSMIKPSECQLEVTTERVQRQSVEEEGGIANYNTSSKEQPVVFNHVYNINVPLDNLCSSGLEASAEQEVSAEDETLAEYMGQTSDHESQVTFTHRINFPKKACPCASSAQVLQELLSRIEMLEREVSVLRDQCNANCCQESAATGQLDYIPHCSGHGNFSFESCGCICNEGWFGKNCSEPYCPLGCSSRGVCVDGQCICDSEYSGDDCSELRCPTDCSSRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKGRCANGTCLCEEGYVGEDCGQRQCLNACSGRGQCEEGLCVCEEGYQGPDCSAVAPPEDLRVAGISDRSIELEWDGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVISNILSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFSFDGWEISFIPKNNEGGVIAQVPSDVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVIDGPTQILVRDVSDTVAFVEWIPPRAKVDFILLKYGLVGGEGGRTTFRLQPPLSQYSVQALRPGSRYEVSVSAVRGTNESDSATTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEVQEYKVVYSTLAGEQYHEVLVPRGIGPTTRATLTDLVPGTEYGVGISAVMNSQQSVPATMNARTELDSPRDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGIASEVTVPKDRTSYTLTDLEPGAEYIISVTAERGRQQSLESTVDAFTGFRPISHLHFSHVTSSSVNITWSDPSPPADRLILNYSPRDEEEEMMEVSLDATKRHAVLMGLQPATEYIVNLVAVHGTVTSEPIVGSITTGIDPPKDITISNVTKDSVMVSWSPPVASFDYYRVSYRPTQVGRLDSSVVPNTVTEFTITRLNPATEYEISLNSVRGREESERICTLVHTAMDNPVDLIATNITPTEALLQWKAPVGEVENYVIVLTHFAVAGETILVDGVSEEFRLVDLLPSTHYTATMYATNGPLTSGTISTNFSTLLDPPANLTASEVTRQSALISWQPPRAEIENYVLTYKSTDGSRKELIVDAEDTWIRLEGLLENTDYTVLLQAAQDTTWSSITSTAFTTGGRVFPHPQDCAQHLMNGDTLSGVYPIFLNGELSQKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNVEDEFWLGLDNIHRITSQGRYELRVDMRDGQEAAFASYDRFSVEDSRNLYKLRIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNGKYGESRHSQGINWYHWKGHEFSIPFVEMKMRPYNHRLMAGRKRQSLQF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix.
Function
- Function:
- Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity).
- Gene Ontology Go:
- cell surface
cytoplasm
extracellular region
membrane raft
nucleoplasm
nucleus
perineuronal net
proteinaceous extracellular matrix
associative learning
axon guidance
cell adhesion
extracellular matrix organization
locomotory exploration behavior
long-term synaptic potentiation
negative regulation of axon extension involved in regeneration
negative regulation of cell-cell adhesion
negative regulation of synaptic transmission
neuromuscular process controlling balance
neuron cell-cell adhesion
positive regulation of synaptic transmission, glutamatergic
positive regulation of transmission of nerve impulse
synapse organization
telencephalon cell migration - Gene Ontology Biological Process:
- associative learning
axon guidance
cell adhesion
extracellular matrix organization
locomotory exploration behavior
long-term synaptic potentiation
negative regulation of axon extension involved in regeneration
negative regulation of cell-cell adhesion
negative regulation of synaptic transmission
neuromuscular process controlling balance
neuron cell-cell adhesion
positive regulation of synaptic transmission, glutamatergic
positive regulation of transmission of nerve impulse
synapse organization
telencephalon cell migration - Gene Ontology Cellular Component:
- cell surface
cytoplasm
extracellular region
membrane raft
nucleoplasm
nucleus
perineuronal net
proteinaceous extracellular matrix - Keywords:
- Alternative splicing
Cell adhesion
Coiled coil
Complete proteome
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Phosphoprotein
Polymorphism
Proteoglycan
Reference proteome
Repeat
Secreted
Sialic acid
Signal