Names & Taxonomy
- Uniprot ID:
- Q92637
- Entry Name:
- FCGRB_HUMAN
- Status:
- reviewed
- Protein Names:
- High affinity immunoglobulin gamma Fc receptor IB (IgG Fc receptor IB) (Fc-gamma RIB) (FcRIB) (hFcgammaRIB)
- Gene Names:
- FCGR1B IGFRB
- Gene Names Primary:
- FCGR1B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 280
- Sequence:
- MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFMEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISQYTVKGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWNLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.
- Cross Reference Drug Bank:
- DB00028
- Gene Ontology Go:
- clathrin-coated endocytic vesicle membrane
early endosome membrane
integral component of membrane
plasma membrane
immunoglobulin receptor activity
adaptive immune response
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cytokine-mediated signaling pathway
Fc receptor signaling pathway
immune response
interferon-gamma-mediated signaling pathway - Gene Ontology Biological Process:
- adaptive immune response
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cytokine-mediated signaling pathway
Fc receptor signaling pathway
immune response
interferon-gamma-mediated signaling pathway - Gene Ontology Molecular Function:
- immunoglobulin receptor activity
- Gene Ontology Cellular Component:
- clathrin-coated endocytic vesicle membrane
early endosome membrane
integral component of membrane
plasma membrane - Keywords:
- Adaptive immunity
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
IgG-binding protein
Immunity
Immunoglobulin domain
Membrane
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix