Names & Taxonomy

Uniprot ID:
Q8WYK2
Entry Name:
JDP2_HUMAN
Status:
reviewed
Protein Names:
Jun dimerization protein 2
Gene Names:
JDP2
Gene Names Primary:
JDP2
Organism:
Homo sapiens (Human)

Structure

Length:
163
Sequence:
MMPGQIPDPSVTTGSLPGLGPLTGLPSSALTVEELKYADIRNLGAMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLLEQLEKK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
Cross Reference Drug Bank:
DB00852
Gene Ontology Go:
nucleus
chromatin binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
negative regulation of fat cell differentiation
positive regulation of histone deacetylation
transcription, DNA-templated
Gene Ontology Biological Process:
negative regulation of fat cell differentiation
positive regulation of histone deacetylation
transcription, DNA-templated
Gene Ontology Molecular Function:
chromatin binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Gene Ontology Cellular Component:
nucleus
Keywords:
Alternative splicing
Complete proteome
DNA-binding
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation
Interacts With:
Q8IU81

Publication

PubMed ID:
12707301 12508121 15489334 12903123 16518400 16026868 18307971 18671972 25218447 25755297