Names & Taxonomy
- Uniprot ID:
- Q8WY07
- Entry Name:
- CTR3_HUMAN
- Status:
- reviewed
- Protein Names:
- Cationic amino acid transporter 3 (CAT-3) (CAT3) (Cationic amino acid transporter y+) (Solute carrier family 7 member 3)
- Gene Names:
- SLC7A3 ATRC3 CAT3
- Gene Names Primary:
- SLC7A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 619
- Sequence:
- MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSRKSRAKTVDLDPGTLYVHSV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.
- Cross Reference Drug Bank:
- DB00125 DB00123 DB00129
- Gene Ontology Go:
- integral component of membrane
plasma membrane
antiporter activity
arginine transmembrane transporter activity
L-lysine transmembrane transporter activity
L-ornithine transmembrane transporter activity
amino acid transport
ion transport
L-ornithine transmembrane transport
regulation of TOR signaling
transmembrane transport - Gene Ontology Biological Process:
- amino acid transport
ion transport
L-ornithine transmembrane transport
regulation of TOR signaling
transmembrane transport - Gene Ontology Molecular Function:
- antiporter activity
arginine transmembrane transporter activity
L-lysine transmembrane transporter activity
L-ornithine transmembrane transporter activity - Gene Ontology Cellular Component:
- integral component of membrane
plasma membrane - Keywords:
- Amino-acid transport
Cell membrane
Complete proteome
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport