Names & Taxonomy
- Uniprot ID:
- Q8WWT9
- Entry Name:
- S13A3_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 13 member 3 (Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (hNaDC3) (Sodium-dependent high-affinity dicarboxylate transporter 2)
- Gene Names:
- SLC13A3 NADC3 SDCT2
- Gene Names Primary:
- SLC13A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 602
- Sequence:
- MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLFNPGFLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETEPLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTALPPTLANDTFRTL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 423 443 Helical.
Function
- Function:
- High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate.
- Cross Reference Drug Bank:
- DB00139
- Gene Ontology Go:
- extracellular exosome
integral component of plasma membrane
plasma membrane
citrate transmembrane transporter activity
high-affinity sodium:dicarboxylate symporter activity
L-aspartate transmembrane transporter activity
sodium:dicarboxylate symporter activity
succinate transmembrane transporter activity
citrate transport
transmembrane transport - Gene Ontology Biological Process:
- citrate transport
transmembrane transport - Gene Ontology Molecular Function:
- citrate transmembrane transporter activity
high-affinity sodium:dicarboxylate symporter activity
L-aspartate transmembrane transporter activity
sodium:dicarboxylate symporter activity
succinate transmembrane transporter activity - Gene Ontology Cellular Component:
- extracellular exosome
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Ion transport
Membrane
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport