Names & Taxonomy
- Uniprot ID:
- Q8WVX9
- Entry Name:
- FACR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Fatty acyl-CoA reductase 1 (EC 1.2.1.n2) (Male sterility domain-containing protein 2)
- Gene Names:
- FAR1 MLSTD2 UNQ2423/PRO4981
- Gene Names Orf:
- UNQ2423/PRO4981
- Gene Names Primary:
- FAR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 515
- Sequence:
- MVSIPEYYEGKNVLLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEVLSGKLFDRLRDENPDFREKIIAINSELTQPKLALSEEDKEVIIDSTNIIFHCAATVRFNENLRDAVQLNVIATRQLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKLIGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILRTIRASNNALADLVPVDVVVNMSLAAAWYSGVNRPRNIMVYNCTTGSTNPFHWGEVEYHVISTFKRNPLEQAFRRPNVNLTSNHLLYHYWIAVSHKAPAFLYDIYLRMTGRSPRMMKTITRLHKAMVFLEYFTSNSWVWNTENVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCLGTKKYVLNEEMSGLPAARKHLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYFVVSLCYKFLSYFRASSTMRY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Peroxisome membrane
Function
- Function:
- Catalyzes the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols.
- Catalytic Activity:
- Hexadecanal + CoA + NADP(+) = hexadecanoyl-CoA + NADPH.
- Gene Ontology Go:
- integral component of membrane
peroxisomal matrix
peroxisomal membrane
peroxisome
fatty-acyl-CoA reductase (alcohol-forming) activity
long-chain-fatty-acyl-CoA reductase activity
cellular lipid metabolic process
ether lipid biosynthetic process
glycerophospholipid biosynthetic process
long-chain fatty-acyl-CoA metabolic process
small molecule metabolic process
wax biosynthetic process - Gene Ontology Biological Process:
- cellular lipid metabolic process
ether lipid biosynthetic process
glycerophospholipid biosynthetic process
long-chain fatty-acyl-CoA metabolic process
small molecule metabolic process
wax biosynthetic process - Gene Ontology Molecular Function:
- fatty-acyl-CoA reductase (alcohol-forming) activity
long-chain-fatty-acyl-CoA reductase activity - Gene Ontology Cellular Component:
- integral component of membrane
peroxisomal matrix
peroxisomal membrane
peroxisome - Keywords:
- Complete proteome
Disease mutation
Epilepsy
Lipid biosynthesis
Lipid metabolism
Membrane
Mental retardation
NADP
Oxidoreductase
Peroxisome
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix - Interacts With:
- Q9BUV8