Names & Taxonomy
- Uniprot ID:
- Q8WUI4
- Entry Name:
- HDAC7_HUMAN
- Status:
- reviewed
- Protein Names:
- Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a)
- Gene Names:
- HDAC7 HDAC7A
- Gene Names Primary:
- HDAC7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 952
- Sequence:
- MDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
Function
- Function:
- Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).
- Catalytic Activity:
- Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
- Active Site:
- ACT_SITE 670 670
- Cross Reference Drug Bank:
- DB06603
- Gene Ontology Go:
- cytoplasm
histone deacetylase complex
nucleoplasm
nucleus
14-3-3 protein binding
activating transcription factor binding
chromatin binding
metal ion binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein kinase binding
protein kinase C binding
repressing transcription factor binding
transcription corepressor activity
cell-cell junction assembly
cellular protein metabolic process
cellular response to mechanical stimulus
negative regulation of interleukin-2 production
negative regulation of neuron death
negative regulation of NIK/NF-kappaB signaling
negative regulation of osteoblast differentiation
negative regulation of transcription from RNA polymerase II promoter
neuron apoptotic process
neuron differentiation
Notch signaling pathway
positive regulation of cell migration involved in sprouting angiogenesis
post-translational protein modification
protein sumoylation
transcription, DNA-templated
vasculogenesis - Gene Ontology Biological Process:
- cell-cell junction assembly
cellular protein metabolic process
cellular response to mechanical stimulus
negative regulation of interleukin-2 production
negative regulation of neuron death
negative regulation of NIK/NF-kappaB signaling
negative regulation of osteoblast differentiation
negative regulation of transcription from RNA polymerase II promoter
neuron apoptotic process
neuron differentiation
Notch signaling pathway
positive regulation of cell migration involved in sprouting angiogenesis
post-translational protein modification
protein sumoylation
transcription, DNA-templated
vasculogenesis - Gene Ontology Molecular Function:
- 14-3-3 protein binding
activating transcription factor binding
chromatin binding
metal ion binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein kinase binding
protein kinase C binding
repressing transcription factor binding
transcription corepressor activity - Gene Ontology Cellular Component:
- cytoplasm
histone deacetylase complex
nucleoplasm
nucleus - Keywords:
- 3D-structure
Alternative splicing
Chromatin regulator
Complete proteome
Cytoplasm
Hydrolase
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Repressor
Transcription
Transcription regulation
Zinc - Interacts With:
- Q13137; P00533; Q9BZS1-1; P08393; Q9BZL6; Q04864; Q0D2K3; P31947; P63104