Names & Taxonomy
- Uniprot ID:
- Q8TCD5
- Entry Name:
- NT5C_HUMAN
- Status:
- reviewed
- Protein Names:
- 5'(3')-deoxyribonucleotidase, cytosolic type (EC 3.1.3.-) (Cytosolic 5',3'-pyrimidine nucleotidase) (Deoxy-5'-nucleotidase 1) (dNT-1)
- Gene Names:
- NT5C DNT1 UMPH2
- Gene Names Primary:
- NT5C
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 201
- Sequence:
- MARSVRVLVDMDGVLADFEAGLLRGFRRRFPEEPHVPLEQRRGFLAREQYRALRPDLADKVASVYEAPGFFLDLEPIPGALDAVREMNDLPDTQVFICTSPLLKYHHCVGEKYRWVEQHLGPQFVERIILTRDKTVVLGDLLIDDKDTVRGQEETPSWEHILFTCCHNRHLVLPPTRRRLLSWSDNWREILDSKRGAAQRE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 10 10 Nucleophile.
- Cross Reference Drug Bank:
- DB00709
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
mitochondrion
nucleus
5'-nucleotidase activity
metal ion binding
nucleotidase activity
pyrimidine nucleotide binding
dephosphorylation
nucleobase-containing small molecule metabolic process
purine nucleobase metabolic process
purine nucleotide catabolic process
pyrimidine deoxyribonucleotide catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- dephosphorylation
nucleobase-containing small molecule metabolic process
purine nucleobase metabolic process
purine nucleotide catabolic process
pyrimidine deoxyribonucleotide catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- 5'-nucleotidase activity
metal ion binding
nucleotidase activity
pyrimidine nucleotide binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
mitochondrion
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Hydrolase
Magnesium
Metal-binding
Nucleotide metabolism
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome