Names & Taxonomy
- Uniprot ID:
- Q8TC12
- Entry Name:
- RDH11_HUMAN
- Status:
- reviewed
- Protein Names:
- Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1)
- Gene Names:
- RDH11 ARSDR1 PSDR1 SDR7C1 CGI-82
- Gene Names Orf:
- CGI-82
- Gene Names Primary:
- RDH11
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 318
- Sequence:
- MVELMFPLLLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLWDVSCDLLGLPID
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected.
- Catalytic Activity:
- All-trans-retinol + NADP(+) = all-trans-retinal + NADPH.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: ; Kinetic parameters: KM=0.23 uM for NADPH
- Active Site:
- ACT_SITE 202 202 Proton acceptor.
- Cross Reference Drug Bank:
- DB00162
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
intracellular
photoreceptor inner segment
NADP-retinol dehydrogenase activity
retinol dehydrogenase activity
adaptation of rhodopsin mediated signaling
fat-soluble vitamin metabolic process
phototransduction, visible light
retinal metabolic process
retinoid metabolic process
retinol metabolic process
small molecule metabolic process
vitamin metabolic process - Gene Ontology Biological Process:
- adaptation of rhodopsin mediated signaling
fat-soluble vitamin metabolic process
phototransduction, visible light
retinal metabolic process
retinoid metabolic process
retinol metabolic process
small molecule metabolic process
vitamin metabolic process - Gene Ontology Molecular Function:
- NADP-retinol dehydrogenase activity
retinol dehydrogenase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
intracellular
photoreceptor inner segment - Keywords:
- Acetylation
Alternative splicing
Cataract
Complete proteome
Dwarfism
Endoplasmic reticulum
Membrane
NADP
Oxidoreductase
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix