Names & Taxonomy
- Uniprot ID:
- Q8TB61
- Entry Name:
- S35B2_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPS transporter 1) (Putative MAPK-activating protein PM15) (Putative NF-kappa-B-activating protein 48) (Solute carrier family 35 member B2)
- Gene Names:
- SLC35B2 PAPST1 PSEC0149
- Gene Names Orf:
- PSEC0149
- Gene Names Primary:
- SLC35B2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 432
- Sequence:
- MDARWWAVVVLAAFPSLGAGGETPEAPPESWTQLWFFRFVVNAAGYASFMVPGYLLVQYFRRKNYLETGRGLCFPLVKACVFGNEPKASDEVPLAPRTEAAETTPMWQALKLLFCATGLQVSYLTWGVLQERVMTRSYGATATSPGERFTDSQFLVLMNRVLALIVAGLSCVLCKQPRHGAPMYRYSFASLSNVLSSWCQYEALKFVSFPTQVLAKASKVIPVMLMGKLVSRRSYEHWEYLTATLISIGVSMFLLSSGPEPRSSPATTLSGLILLAGYIAFDSFTSNWQDALFAYKMSSVQMMFGVNFFSCLFTVGSLLEQGALLEGTRFMGRHSEFAAHALLLSICSACGQLFIFYTIGQFGAAVFTIIMTLRQAFAILLSCLLYGHTVTVVGGLGVAVVFAALLLRVYARGRLKQRGKKAVPVESPVQKV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus membrane
Function
- Function:
- Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.8 uM for PAPS
- Gene Ontology Go:
- Golgi apparatus
Golgi membrane
integral component of membrane
membrane
3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity
signal transducer activity
3'-phospho-5'-adenylyl sulfate transmembrane transport
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
3'-phosphoadenosine 5'-phosphosulfate metabolic process
3'-phosphoadenosine 5'-phosphosulfate transport
carbohydrate metabolic process
glycosaminoglycan metabolic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
signal transduction
small molecule metabolic process
transmembrane transport
xenobiotic metabolic process - Gene Ontology Biological Process:
- 3'-phospho-5'-adenylyl sulfate transmembrane transport
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
3'-phosphoadenosine 5'-phosphosulfate metabolic process
3'-phosphoadenosine 5'-phosphosulfate transport
carbohydrate metabolic process
glycosaminoglycan metabolic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
signal transduction
small molecule metabolic process
transmembrane transport
xenobiotic metabolic process - Gene Ontology Molecular Function:
- 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity
signal transducer activity - Gene Ontology Cellular Component:
- Golgi apparatus
Golgi membrane
integral component of membrane
membrane - Keywords:
- Alternative splicing
Complete proteome
Golgi apparatus
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport