Names & Taxonomy

Uniprot ID:
Q8TAD4
Entry Name:
ZNT5_HUMAN
Status:
reviewed
Protein Names:
Zinc transporter 5 (ZnT-5) (Solute carrier family 30 member 5) (ZnT-like transporter 1) (hZTL1)
Gene Names:
SLC30A5 ZNT5 ZNTL1 ZTL1 UNQ863/PRO1879
Gene Names Orf:
UNQ863/PRO1879
Gene Names Primary:
SLC30A5
Organism:
Homo sapiens (Human)

Structure

Length:
765
Sequence:
MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKAVGLFESYDLLKAVHIVQFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLRTLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPEGHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQALSHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSKCARYGSFPIFISALLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSAIFFILSANILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAFSHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVNNLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Golgi apparatus, trans-Golgi network membrane

Function

Function:
Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.
Gene Ontology Go:
apical plasma membrane
Golgi apparatus
integral component of plasma membrane
membrane
nucleolus
nucleus
secretory granule
secretory granule membrane
zinc ion binding
zinc ion transmembrane transporter activity
cellular protein metabolic process
cellular zinc ion homeostasis
cobalt ion transport
regulation of proton transport
regulation of sequestering of zinc ion
response to zinc ion
transmembrane transport
zinc II ion transmembrane transport
zinc II ion transport
Gene Ontology Biological Process:
cellular protein metabolic process
cellular zinc ion homeostasis
cobalt ion transport
regulation of proton transport
regulation of sequestering of zinc ion
response to zinc ion
transmembrane transport
zinc II ion transmembrane transport
zinc II ion transport
Gene Ontology Molecular Function:
zinc ion binding
zinc ion transmembrane transporter activity
Gene Ontology Cellular Component:
apical plasma membrane
Golgi apparatus
integral component of plasma membrane
membrane
nucleolus
nucleus
secretory granule
secretory granule membrane
Keywords:
Acetylation
Alternative splicing
Complete proteome
Golgi apparatus
Ion transport
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Transport
Zinc
Zinc transport

Publication

PubMed ID:
11904301 11937503 15276077 12975309 14702039 17974005 15372022 15489334 15994300 15525635 18691976 20068231 22814378 25582195