Names & Taxonomy
- Uniprot ID:
- Q8NFW8
- Entry Name:
- NEUA_HUMAN
- Status:
- reviewed
- Protein Names:
- N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase)
- Gene Names:
- CMAS
- Gene Names Primary:
- CMAS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 434
- Sequence:
- MDSVEKGAATSVSNPRGRPSRGRPPKLQRNSRGGQGRGVEKPPHLAALILARGGSKGIPLKNIKHLAGVPLIGWVLRAALDSGAFQSVWVSTDHDEIENVAKQFGAQVHRRSSEVSKDSSTSLDAIIEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRYGYFGKEKLKEIKLLVCNIDGCLTNGHIYVSGDQKEIISYDVKDAIGISLLKKSGIEVRLISERACSKQTLSSLKLDCKMEVSVSDKLAVVDEWRKEMGLCWKEVAYLGNEVSDEECLKRVGLSGAPADACSTAQKAVGYICKCNGGRGAIREFAEHICLLMEKVNNSCQK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
- Pathway:
- Amino-sugar metabolism; N-acetylneuraminate metabolism.
- Catalytic Activity:
- CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.
- Active Site:
- ACT_SITE 201 201
- Gene Ontology Go:
- cytosol
membrane
nucleoplasm
nucleus
N-acylneuraminate cytidylyltransferase activity
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
N-acetylneuraminate metabolic process
post-translational protein modification
protein N-linked glycosylation via asparagine - Gene Ontology Biological Process:
- cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
N-acetylneuraminate metabolic process
post-translational protein modification
protein N-linked glycosylation via asparagine - Gene Ontology Molecular Function:
- N-acylneuraminate cytidylyltransferase activity
- Gene Ontology Cellular Component:
- cytosol
membrane
nucleoplasm
nucleus - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Nucleotidyltransferase
Nucleus
Reference proteome
Transferase