Names & Taxonomy
- Uniprot ID:
- Q8NFJ6
- Entry Name:
- PKR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Prokineticin receptor 2 (PK-R2) (G-protein coupled receptor 73-like 1) (G-protein coupled receptor I5E) (GPR73b) (GPRg2)
- Gene Names:
- PROKR2 GPR73L1 PKR2
- Gene Names Primary:
- PROKR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 384
- Sequence:
- MAAQNGNTSFTPNFNPPQDHASSLSFNFSYGDYDLPMDEDEDMTKTRTFFAAKIVIGIALAGIMLVCGIGNFVFIAALTRYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFATETVLFIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYFKKMMLLHWRPSQRGSKSSADLDLRTNGVPTTEEVDCIRLK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
G-protein coupled receptor activity
neuropeptide Y receptor activity
cell surface receptor signaling pathway
circadian rhythm
G-protein coupled receptor signaling pathway - Gene Ontology Biological Process:
- cell surface receptor signaling pathway
circadian rhythm
G-protein coupled receptor signaling pathway - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
neuropeptide Y receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disease mutation
Disulfide bond
G-protein coupled receptor
Glycoprotein
Hypogonadotropic hypogonadism
Kallmann syndrome
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix