Names & Taxonomy

Uniprot ID:
Q8NFF2
Entry Name:
NCKX4_HUMAN
Status:
reviewed
Protein Names:
Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4)
Gene Names:
SLC24A4 NCKX4
Gene Names Primary:
SLC24A4
Organism:
Homo sapiens (Human)

Structure

Length:
622
Sequence:
MALRGTLRPLKVRRRREMLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity).
Gene Ontology Go:
cytoplasm
integral component of plasma membrane
membrane
plasma membrane
calcium channel activity
calcium ion binding
calcium, potassium:sodium antiporter activity
potassium ion binding
sodium ion binding
symporter activity
amelogenesis
cellular calcium ion homeostasis
ion transport
response to stimulus
sensory perception of smell
transmembrane transport
Gene Ontology Biological Process:
amelogenesis
cellular calcium ion homeostasis
ion transport
response to stimulus
sensory perception of smell
transmembrane transport
Gene Ontology Molecular Function:
calcium, potassium:sodium antiporter activity
calcium channel activity
calcium ion binding
potassium ion binding
sodium ion binding
symporter activity
Gene Ontology Cellular Component:
cytoplasm
integral component of plasma membrane
membrane
plasma membrane
Keywords:
Alternative splicing
Amelogenesis imperfecta
Antiport
Calcium
Calcium transport
Complete proteome
Cytoplasm
Disease mutation
Glycoprotein
Ion transport
Membrane
Olfaction
Polymorphism
Potassium
Potassium transport
Reference proteome
Repeat
Sensory transduction
Signal
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
12379639 14702039 12508121 15489334 17974005 17952075 23375655 24621671