Names & Taxonomy
- Uniprot ID:
- Q8NCK7
- Entry Name:
- MOT11_HUMAN
- Status:
- reviewed
- Protein Names:
- Monocarboxylate transporter 11 (MCT 11) (Solute carrier family 16 member 11)
- Gene Names:
- SLC16A11 MCT11
- Gene Names Primary:
- SLC16A11
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 471
- Sequence:
- MPAPQRKHRRGGFSHRCFPTPQTAMTPQPAGPPDGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTPCGALLLPLVLPGDPPAPPRSPLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGEESWGGPLLAAAVAYGLSAGSYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGFLRDETGDFTASFLLSGSLILSGSFIYIGLPRALPSCGPASPPATPPPETGELLPAPQAVLLSPGGPGSTLDTTC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of plasma membrane
lactate transmembrane transporter activity
symporter activity
lipid metabolic process
plasma membrane lactate transport - Gene Ontology Biological Process:
- lipid metabolic process
plasma membrane lactate transport - Gene Ontology Molecular Function:
- lactate transmembrane transporter activity
symporter activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of plasma membrane - Keywords:
- Complete proteome
Diabetes mellitus
Endoplasmic reticulum
Lipid metabolism
Membrane
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport