Names & Taxonomy
- Uniprot ID:
- Q8NBW4
- Entry Name:
- S38A9_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium-coupled neutral amino acid transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11)
- Gene Names:
- SLC38A9 URLC11
- Gene Names Primary:
- SLC38A9
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 561
- Sequence:
- MANMNSDSRHLGTSEVDHERDPGPMNIQFEPSDLRSKRPFCIEPTNIVNVNHVIQRVSDHASAMNKRIHYYSRLTTPADKALIAPDHVVPAPEECYVYSPLGSAYKLQSYTEGYGKNTSLVTIFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIILMGLLTLYCCYRVVKSRTMMFSLDTTSWEYPDVCRHYFGSFGQWSSLLFSLVSLIGAMIVYWVLMSNFLFNTGKFIFNFIHHINDTDTILSTNNSNPVICPSAGSGGHPDNSSMIFYANDTGAQQFEKWWDKSRTVPFYLVGLLLPLLNFKSPSFFSKFNILGTVSVLYLIFLVTFKAVRLGFHLEFHWFIPTEFFVPEIRFQFPQLTGVLTLAFFIHNCIITLLKNNKKQENNVRDLCIAYMLVTLTYLYIGVLVFASFPSPPLSKDCIEQNFLDNFPSSDTLSFIARIFLLFQMMTVYPLLGYLARVQLLGHIFGDIYPSIFHVLILNLIIVGAGVIMACFYPNIGGIIRYSGAACGLAFVFIYPSLIYIISLHQEERLTWPKLIFHVFIIILGVANLIVQFFM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome membrane
Function
- Function:
- Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acids. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:25561175, PubMed:25567906). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids, suggesting that it acts as an amino acid sensor instead (PubMed:25561175, PubMed:25567906). The high concentration of arginine in lysosomes suggests that it acts as an arginine sensor (PubMed:25567906).
- Gene Ontology Go:
- endoplasmic reticulum
integral component of membrane
late endosome
late endosome membrane
lysosomal membrane
lysosome
amino acid transmembrane transporter activity
amino acid transmembrane transport
cellular response to amino acid stimulus
positive regulation of TOR signaling - Gene Ontology Biological Process:
- amino acid transmembrane transport
cellular response to amino acid stimulus
positive regulation of TOR signaling - Gene Ontology Molecular Function:
- amino acid transmembrane transporter activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum
integral component of membrane
late endosome
late endosome membrane
lysosomal membrane
lysosome - Keywords:
- Alternative splicing
Amino-acid transport
Complete proteome
Endosome
Glycoprotein
Lysosome
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q6IAA8; Q9UHA4; Q0VGL1; O43504; Q7L523; Q9HB90