Names & Taxonomy

Uniprot ID:
Q8NBH6
Entry Name:
Q8NBH6_HUMAN
Status:
unreviewed
Protein Names:
Fibulin-1
Organism:
Homo sapiens (Human)

Structure

Length:
638
Sequence:
MSSWRPAVRTDTGWPLIRRTARCHMLRNPKNAGWCRSSAATASWRSCTVPRASAWPTSRTAVPRPMVGYQCGQVFRACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF

Subcellular location

Subcellular Location:
Secreted, extracellular space, extracellular matrix

Function

Function:
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
Gene Ontology Go:
intracellular
proteinaceous extracellular matrix
calcium ion binding
integrin binding
peptidase activator activity
extracellular matrix organization
Gene Ontology Biological Process:
extracellular matrix organization
Gene Ontology Molecular Function:
calcium ion binding
integrin binding
peptidase activator activity
Gene Ontology Cellular Component:
intracellular
proteinaceous extracellular matrix
Keywords:
Calcium
Disulfide bond
EGF-like domain
Extracellular matrix
Repeat
Secreted