Names & Taxonomy
- Uniprot ID:
- Q8N142
- Entry Name:
- PURA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenylosuccinate synthetase isozyme 1 (AMPSase 1) (AdSS 1) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme) (Adenylosuccinate synthetase, muscle isozyme) (M-type adenylosuccinate synthetase) (IMP--aspartate ligase 1)
- Gene Names:
- ADSSL1 ADSS1
- Gene Names Primary:
- ADSSL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 457
- Sequence:
- MSGTRASNDRPPGAGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLVFDFHQAVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDFDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQLF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
- Pathway:
- Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.
- Catalytic Activity:
- GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 43 43 Proton acceptor.
- Cross Reference Drug Bank:
- DB00128
- Gene Ontology Go:
- cytoplasm
cytosol
adenylosuccinate synthase activity
GTP binding
GTPase activity
magnesium ion binding
phosphate ion binding
'de novo' AMP biosynthetic process
AMP biosynthetic process
aspartate metabolic process
cellular response to drug
cellular response to electrical stimulus
glutamine metabolic process
immune system process
IMP metabolic process
nucleobase-containing small molecule metabolic process
purine nucleobase metabolic process
purine ribonucleoside monophosphate biosynthetic process
response to muscle activity
response to starvation
small molecule metabolic process - Gene Ontology Biological Process:
- 'de novo' AMP biosynthetic process
AMP biosynthetic process
aspartate metabolic process
cellular response to drug
cellular response to electrical stimulus
glutamine metabolic process
immune system process
IMP metabolic process
nucleobase-containing small molecule metabolic process
purine nucleobase metabolic process
purine ribonucleoside monophosphate biosynthetic process
response to muscle activity
response to starvation
small molecule metabolic process - Gene Ontology Molecular Function:
- adenylosuccinate synthase activity
GTPase activity
GTP binding
magnesium ion binding
phosphate ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
GTP-binding
Ligase
Magnesium
Metal-binding
Nucleotide-binding
Purine biosynthesis
Reference proteome