Names & Taxonomy

Uniprot ID:
Q8N122
Entry Name:
RPTOR_HUMAN
Status:
reviewed
Protein Names:
Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein)
Gene Names:
RPTOR KIAA1303 RAPTOR
Gene Names Primary:
RPTOR
Organism:
Homo sapiens (Human)

Structure

Length:
1335
Sequence:
MESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSSARELRPLLVFIWAKILAVDSSCQADLVKDNGHKYFLSVLADPYMPAEHRTMTAFILAVIVNSYHTGQEACLQGNLIAICLEQLNDPHPLLRQWVAICLGRIWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALGTFVGNSAERTDHSTTIDHNVAMMLAQLVSDGSPMVRKELVVALSHLVVQYESNFCTVALQFIEEEKNYALPSPATTEGGSLTPVRDSPCTPRLRSVSSYGNIRAVATARSLNKSLQNLSLTEESGGAVAFSPGNLSTSSSASSTLGSPENEEHILSFETIDKMRRASSYSSLNSLIGVSFNSVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIAYKATVNARPQRVLDTSSLTQSAPASPTNKGVHIHQAGGSPPASSTSSSSLTNDVAKQPVSRDLPSGRPGTTGPAGAQYTPHSHQFPRTRKMFDKGPEQTADDADDAAGHKSFISATVQTGFCDWSARYFAQPVMKIPEEHDLESQIRKEREWRFLRNSRVRRQAQQVIQKGITRLDDQIFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTALDIHPQADLIACGSVNQFTAIYNSSGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVEKRVR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm. Lysosome. Cytoplasmic granule. Note=Targeting to lysosomes depends on amino acid availability. In arsenite-stressed cells, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased.

Function

Function:
Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.
Gene Ontology Go:
cytoplasm
cytosol
dendrite
intracellular membrane-bounded organelle
lysosomal membrane
lysosome
neuronal cell body
nucleoplasm
TORC1 complex
14-3-3 protein binding
protein complex binding
protein kinase binding
RNA polymerase III type 1 promoter DNA binding
RNA polymerase III type 2 promoter DNA binding
RNA polymerase III type 3 promoter DNA binding
TFIIIC-class transcription factor binding
cell cycle arrest
cell growth
cellular response to amino acid stimulus
cellular response to heat
cellular response to nutrient levels
gene expression
insulin receptor signaling pathway
macroautophagy
positive regulation of endothelial cell proliferation
positive regulation of protein serine/threonine kinase activity
positive regulation of TOR signaling
positive regulation of transcription from RNA polymerase III promoter
regulation of cell size
regulation of cellular response to heat
TOR signaling
transcription initiation from RNA polymerase II promoter
Gene Ontology Biological Process:
cell cycle arrest
cell growth
cellular response to amino acid stimulus
cellular response to heat
cellular response to nutrient levels
gene expression
insulin receptor signaling pathway
macroautophagy
positive regulation of endothelial cell proliferation
positive regulation of protein serine/threonine kinase activity
positive regulation of TOR signaling
positive regulation of transcription from RNA polymerase III promoter
regulation of cell size
regulation of cellular response to heat
TOR signaling
transcription initiation from RNA polymerase II promoter
Gene Ontology Molecular Function:
14-3-3 protein binding
protein complex binding
protein kinase binding
RNA polymerase III type 1 promoter DNA binding
RNA polymerase III type 2 promoter DNA binding
RNA polymerase III type 3 promoter DNA binding
TFIIIC-class transcription factor binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
dendrite
intracellular membrane-bounded organelle
lysosomal membrane
lysosome
neuronal cell body
nucleoplasm
TORC1 complex
Keywords:
Alternative splicing
Complete proteome
Cytoplasm
Lysosome
Phosphoprotein
Reference proteome
Repeat
WD repeat
Interacts With:
Q13541; Q13283; Q9P2J5; Q9BVC4; Q13615; P42345; Q9JLN9; Q8TCU6; P62820; P67999; Q9HB90; Q96EB6; Q96R06

Publication

PubMed ID:
12150925 12150926 16625196 15489334 10718198 19388141 12408816 12747827 15066126 17081983 16964243 17386266 18722121 18220336 18439900 18691976 18669648 19413330 19211835 19369195 19690332 20381137 19864431 20068231 21269460 21406692 23027611 22493283 23953116 24036451 23727834 25657994 24275569