Names & Taxonomy

Uniprot ID:
Q8IZY2
Entry Name:
ABCA7_HUMAN
Status:
reviewed
Protein Names:
ATP-binding cassette sub-family A member 7 (ABCA-SSN) (Autoantigen SS-N) (Macrophage ABC transporter)
Gene Names:
ABCA7
Gene Names Primary:
ABCA7
Organism:
Homo sapiens (Human)

Structure

Length:
2146
Sequence:
MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHRTLAGLGKLIATLRAARSTAQPQPTKQSPLEPPMLDVAELLTSLLRTESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVELRALLQRPRGTSGPLELLSEALCSVRGPSSTVGPSLNWYEASDLMELVGQEPESALPDSSLSPACSELIGALDSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFMNDSSNVAMLQRLLQMQDEGRRQPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQPRVRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDTEEQKEAGVGVDPAPGLQHPKRVSQFLDDPSTAETVL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.
Gene Ontology Go:
apical plasma membrane
ATP-binding cassette (ABC) transporter complex
cell junction
cell surface
early endosome membrane
Golgi apparatus
Golgi membrane
integral component of membrane
intracellular membrane-bounded organelle
phagocytic cup
plasma membrane
ruffle membrane
apolipoprotein A-I receptor activity
ATP binding
ATPase activity, coupled to transmembrane movement of substances
phospholipid transporter activity
transporter activity
apolipoprotein A-I-mediated signaling pathway
cholesterol efflux
high-density lipoprotein particle assembly
memory
negative regulation of amyloid precursor protein biosynthetic process
negative regulation of ATPase activity
negative regulation of beta-amyloid formation
peptide cross-linking
phagocytosis
phospholipid efflux
phospholipid scrambling
positive regulation of ATPase activity
positive regulation of beta-amyloid clearance
positive regulation of cholesterol efflux
positive regulation of engulfment of apoptotic cell
positive regulation of ERK1 and ERK2 cascade
positive regulation of phagocytosis
positive regulation of phospholipid efflux
protein localization to nucleus
transmembrane transport
Gene Ontology Biological Process:
apolipoprotein A-I-mediated signaling pathway
cholesterol efflux
high-density lipoprotein particle assembly
memory
negative regulation of amyloid precursor protein biosynthetic process
negative regulation of ATPase activity
negative regulation of beta-amyloid formation
peptide cross-linking
phagocytosis
phospholipid efflux
phospholipid scrambling
positive regulation of ATPase activity
positive regulation of beta-amyloid clearance
positive regulation of cholesterol efflux
positive regulation of engulfment of apoptotic cell
positive regulation of ERK1 and ERK2 cascade
positive regulation of phagocytosis
positive regulation of phospholipid efflux
protein localization to nucleus
transmembrane transport
Gene Ontology Molecular Function:
apolipoprotein A-I receptor activity
ATPase activity, coupled to transmembrane movement of substances
ATP binding
phospholipid transporter activity
transporter activity
Gene Ontology Cellular Component:
apical plasma membrane
ATP-binding cassette (ABC) transporter complex
cell junction
cell surface
early endosome membrane
Golgi apparatus
Golgi membrane
integral component of membrane
intracellular membrane-bounded organelle
phagocytic cup
plasma membrane
ruffle membrane
Keywords:
ATP-binding
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Endosome
Glycoprotein
Golgi apparatus
Membrane
Nucleotide-binding
Phagocytosis
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
10873640 11095984 11355874 11435699 15057824 14592415 12917409 12925201 14570867 12111378