Names & Taxonomy

Uniprot ID:
Q8IYM9
Entry Name:
TRI22_HUMAN
Status:
reviewed
Protein Names:
E3 ubiquitin-protein ligase TRIM22 (EC 6.3.2.-) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (Staf-50) (Tripartite motif-containing protein 22)
Gene Names:
TRIM22 RNF94 STAF50
Gene Names Primary:
TRIM22
Organism:
Homo sapiens (Human)

Structure

Length:
498
Sequence:
MDFSVKVDIEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIKESVIISRGESSCPVCQTRFQPGNLRPNRHLANIVERVKEVKMSPQEGQKRDVCEHHGKKLQIFCKEDGKVICWVCELSQEHQGHQTFRINEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKNYIQIERQKILKGFNEMRVILDNEEQRELQKLEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQRRLRGSSVEMLQDVIDVMKRSESWTLKKPKSVSKKLKSVFRVPDLSGMLQVLKELTDVQYYWVDVMLNPGSATSNVAISVDQRQVKTVRTCTFKNSNPCDFSAFGVFGCQYFSSGKYYWEVDVSGKIAWILGVHSKISSLNKRKSSGFAFDPSVNYSKVYSRYRPQYGYWVIGLQNTCEYNAFEDSSSSDPKVLTLFMAVPPCRIGVFLDYEAGIVSFFNVTNHGALIYKFSGCRFSRPAYPYFNPWNCLVPMTVCPPSS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
Pathway:
Protein modification; protein ubiquitination.
Gene Ontology Go:
Cajal body
cytoplasm
cytosol
nuclear speck
nucleoplasm
nucleus
ligase activity
protein binding, bridging
protein kinase binding
transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding
cytokine-mediated signaling pathway
defense response to virus
immune response
interferon-gamma-mediated signaling pathway
negative regulation of nucleic acid-templated transcription
positive regulation of autophagy
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of NF-kappaB transcription factor activity
positive regulation of sequence-specific DNA binding transcription factor activity
protein trimerization
protein ubiquitination
regulation of protein localization
regulation of transcription, DNA-templated
response to virus
transcription, DNA-templated
viral process
Gene Ontology Biological Process:
cytokine-mediated signaling pathway
defense response to virus
immune response
interferon-gamma-mediated signaling pathway
negative regulation of nucleic acid-templated transcription
positive regulation of autophagy
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of NF-kappaB transcription factor activity
positive regulation of sequence-specific DNA binding transcription factor activity
protein trimerization
protein ubiquitination
regulation of protein localization
regulation of transcription, DNA-templated
response to virus
transcription, DNA-templated
viral process
Gene Ontology Molecular Function:
ligase activity
protein binding, bridging
protein kinase binding
transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding
Gene Ontology Cellular Component:
Cajal body
cytoplasm
cytosol
nuclear speck
nucleoplasm
nucleus
Keywords:
Alternative splicing
Antiviral defense
Coiled coil
Complete proteome
Cytoplasm
Host-virus interaction
Ligase
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation
Ubl conjugation pathway
Zinc
Zinc-finger

Publication

PubMed ID:
7797467 15489334 11331580 15064739 17156811 18656448 18389079 19331816 19481078 19585648 19218198 21269460