Names & Taxonomy
- Uniprot ID:
- Q8IYM9
- Entry Name:
- TRI22_HUMAN
- Status:
- reviewed
- Protein Names:
- E3 ubiquitin-protein ligase TRIM22 (EC 6.3.2.-) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (Staf-50) (Tripartite motif-containing protein 22)
- Gene Names:
- TRIM22 RNF94 STAF50
- Gene Names Primary:
- TRIM22
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 498
- Sequence:
- MDFSVKVDIEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIKESVIISRGESSCPVCQTRFQPGNLRPNRHLANIVERVKEVKMSPQEGQKRDVCEHHGKKLQIFCKEDGKVICWVCELSQEHQGHQTFRINEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKNYIQIERQKILKGFNEMRVILDNEEQRELQKLEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQRRLRGSSVEMLQDVIDVMKRSESWTLKKPKSVSKKLKSVFRVPDLSGMLQVLKELTDVQYYWVDVMLNPGSATSNVAISVDQRQVKTVRTCTFKNSNPCDFSAFGVFGCQYFSSGKYYWEVDVSGKIAWILGVHSKISSLNKRKSSGFAFDPSVNYSKVYSRYRPQYGYWVIGLQNTCEYNAFEDSSSSDPKVLTLFMAVPPCRIGVFLDYEAGIVSFFNVTNHGALIYKFSGCRFSRPAYPYFNPWNCLVPMTVCPPSS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
- Pathway:
- Protein modification; protein ubiquitination.
- Gene Ontology Go:
- Cajal body
cytoplasm
cytosol
nuclear speck
nucleoplasm
nucleus
ligase activity
protein binding, bridging
protein kinase binding
transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding
cytokine-mediated signaling pathway
defense response to virus
immune response
interferon-gamma-mediated signaling pathway
negative regulation of nucleic acid-templated transcription
positive regulation of autophagy
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of NF-kappaB transcription factor activity
positive regulation of sequence-specific DNA binding transcription factor activity
protein trimerization
protein ubiquitination
regulation of protein localization
regulation of transcription, DNA-templated
response to virus
transcription, DNA-templated
viral process - Gene Ontology Biological Process:
- cytokine-mediated signaling pathway
defense response to virus
immune response
interferon-gamma-mediated signaling pathway
negative regulation of nucleic acid-templated transcription
positive regulation of autophagy
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of NF-kappaB transcription factor activity
positive regulation of sequence-specific DNA binding transcription factor activity
protein trimerization
protein ubiquitination
regulation of protein localization
regulation of transcription, DNA-templated
response to virus
transcription, DNA-templated
viral process - Gene Ontology Molecular Function:
- ligase activity
protein binding, bridging
protein kinase binding
transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- Cajal body
cytoplasm
cytosol
nuclear speck
nucleoplasm
nucleus - Keywords:
- Alternative splicing
Antiviral defense
Coiled coil
Complete proteome
Cytoplasm
Host-virus interaction
Ligase
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation
Ubl conjugation pathway
Zinc
Zinc-finger