Names & Taxonomy

Uniprot ID:
Q8IX30
Entry Name:
SCUB3_HUMAN
Status:
reviewed
Protein Names:
Signal peptide, CUB and EGF-like domain-containing protein 3
Gene Names:
SCUBE3 CEGF3
Gene Names Primary:
SCUBE3
Organism:
Homo sapiens (Human)

Structure

Length:
993
Sequence:
MGSGRVPGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIKQRASFKIKDAKCRLHLRNKGKTEEAGRITGPGGAPCSECQVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLELEAEVRAEETTASCGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLVAGERAEPMESCRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVECIWNINPPPKRKILIVVPEIFLPSEDECGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKLWINFKTSEANSARGFQIPYVTYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHPQNYFKYTEKHKEMLPKSFIKLLRSKVSSFLRPYK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.
Gene Ontology Go:
cell surface
extracellular region
calcium ion binding
protein heterooligomerization
protein homooligomerization
Gene Ontology Biological Process:
protein heterooligomerization
protein homooligomerization
Gene Ontology Molecular Function:
calcium ion binding
Gene Ontology Cellular Component:
cell surface
extracellular region
Keywords:
Alternative splicing
Calcium
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Interacts With:
P08253; P14780; P37173

Publication

PubMed ID:
15234972 14702039 14574404 15489334 17974005 21441952