Names & Taxonomy

Uniprot ID:
Q8IWV2
Entry Name:
CNTN4_HUMAN
Status:
reviewed
Protein Names:
Contactin-4 (Brain-derived immunoglobulin superfamily protein 2) (BIG-2)
Gene Names:
CNTN4
Gene Names Primary:
CNTN4
Organism:
Homo sapiens (Human)

Structure

Length:
1026
Sequence:
MRLPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted

Function

Function:
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
Gene Ontology Go:
anchored component of membrane
axon
extracellular region
plasma membrane
axon guidance
axonal fasciculation
axonogenesis
brain development
negative regulation of neuron differentiation
nervous system development
neuron cell-cell adhesion
neuron projection development
regulation of synaptic plasticity
Gene Ontology Biological Process:
axonal fasciculation
axon guidance
axonogenesis
brain development
negative regulation of neuron differentiation
nervous system development
neuron cell-cell adhesion
neuron projection development
regulation of synaptic plasticity
Gene Ontology Cellular Component:
anchored component of membrane
axon
extracellular region
plasma membrane
Keywords:
Alternative splicing
Cell adhesion
Cell membrane
Chromosomal rearrangement
Complete proteome
Disulfide bond
GPI-anchor
Glycoprotein
Immunoglobulin domain
Lipoprotein
Membrane
Polymorphism
Reference proteome
Repeat
Secreted
Signal

Publication

PubMed ID:
12202991 14571131 14702039 16641997 15489334 11013081 15106122 16335952 20133774 16959974