Names & Taxonomy
- Uniprot ID:
- Q8IWU9
- Entry Name:
- TPH2_HUMAN
- Status:
- reviewed
- Protein Names:
- Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Neuronal tryptophan hydroxylase) (Tryptophan 5-monooxygenase 2)
- Gene Names:
- TPH2 NTPH
- Gene Names Primary:
- TPH2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 490
- Sequence:
- MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI
- Proteomes:
- UP000005640
Function
- Pathway:
- Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
- Catalytic Activity:
- L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.
- Cofactor:
- COFACTOR: Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=41.3 uM for L-tryptophan
- Cross Reference Drug Bank:
- DB00150
- Gene Ontology Go:
- cytosol
neuron projection
amino acid binding
iron ion binding
tryptophan 5-monooxygenase activity
aromatic amino acid family metabolic process
cellular nitrogen compound metabolic process
cellular response to lithium ion
circadian rhythm
indolalkylamine biosynthetic process
response to activity
response to calcium ion
response to estrogen
response to glucocorticoid
response to nutrient levels
serotonin biosynthetic process
small molecule metabolic process - Gene Ontology Biological Process:
- aromatic amino acid family metabolic process
cellular nitrogen compound metabolic process
cellular response to lithium ion
circadian rhythm
indolalkylamine biosynthetic process
response to activity
response to calcium ion
response to estrogen
response to glucocorticoid
response to nutrient levels
serotonin biosynthetic process
small molecule metabolic process - Gene Ontology Molecular Function:
- amino acid binding
iron ion binding
tryptophan 5-monooxygenase activity - Gene Ontology Cellular Component:
- cytosol
neuron projection - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Disease mutation
Iron
Metal-binding
Monooxygenase
Oxidoreductase
Phosphoprotein
Polymorphism
RNA editing
Reference proteome
Serotonin biosynthesis