Names & Taxonomy
- Uniprot ID:
- Q8IWT1
- Entry Name:
- SCN4B_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium channel subunit beta-4
- Gene Names:
- SCN4B
- Gene Names Primary:
- SCN4B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 228
- Sequence:
- MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPSKV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.
- Cross Reference Drug Bank:
- DB00313 DB00909
- Gene Ontology Go:
- intercalated disc
intrinsic component of plasma membrane
voltage-gated sodium channel complex
ion channel binding
sodium channel regulator activity
voltage-gated sodium channel activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
AV node cell action potential
cardiac muscle cell action potential involved in contraction
cardiac muscle contraction
membrane depolarization during cardiac muscle cell action potential
positive regulation of sodium ion transport
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transporter activity
regulation of ventricular cardiac muscle cell membrane repolarization
sodium ion transmembrane transport
sodium ion transport - Gene Ontology Biological Process:
- AV node cell action potential
cardiac muscle cell action potential involved in contraction
cardiac muscle contraction
membrane depolarization during cardiac muscle cell action potential
positive regulation of sodium ion transport
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transporter activity
regulation of ventricular cardiac muscle cell membrane repolarization
sodium ion transmembrane transport
sodium ion transport - Gene Ontology Molecular Function:
- ion channel binding
sodium channel regulator activity
voltage-gated sodium channel activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential - Gene Ontology Cellular Component:
- intercalated disc
intrinsic component of plasma membrane
voltage-gated sodium channel complex - Keywords:
- 3D-structure
Alternative splicing
Atrial fibrillation
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Ion channel
Ion transport
Long QT syndrome
Membrane
Reference proteome
Signal
Sodium
Sodium channel
Sodium transport
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel