Names & Taxonomy
- Uniprot ID:
- Q8IWL2
- Entry Name:
- SFTA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Pulmonary surfactant-associated protein A1 (PSP-A) (PSPA) (SP-A) (SP-A1) (35 kDa pulmonary surfactant-associated protein) (Alveolar proteinosis protein) (Collectin-4)
- Gene Names:
- SFTPA1 COLEC4 PSAP SFTP1 SFTPA SFTPA1B
- Gene Names Primary:
- SFTPA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 248
- Sequence:
- MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
Function
- Function:
- In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
- Gene Ontology Go:
- clathrin-coated endocytic vesicle
collagen trimer
endoplasmic reticulum membrane
extracellular region
extracellular space
lamellar body
proteinaceous extracellular matrix
carbohydrate binding
lipid transporter activity
cellular protein metabolic process
lipid transport
respiratory gaseous exchange - Gene Ontology Biological Process:
- cellular protein metabolic process
lipid transport
respiratory gaseous exchange - Gene Ontology Molecular Function:
- carbohydrate binding
lipid transporter activity - Gene Ontology Cellular Component:
- clathrin-coated endocytic vesicle
collagen trimer
endoplasmic reticulum membrane
extracellular region
extracellular space
lamellar body
proteinaceous extracellular matrix - Keywords:
- Acetylation
Alternative splicing
Calcium
Collagen
Complete proteome
Disulfide bond
Extracellular matrix
Gaseous exchange
Glycoprotein
Hydroxylation
Lectin
Polymorphism
Reference proteome
Secreted
Signal
Surface film - Interacts With:
- Q9UGM3