Names & Taxonomy

Uniprot ID:
Q8IVM8
Entry Name:
S22A9_HUMAN
Status:
reviewed
Protein Names:
Solute carrier family 22 member 9 (Organic anion transporter 7)
Gene Names:
SLC22A9 hOAT4 OAT7 UST3
Gene Names Primary:
SLC22A9
Organism:
Homo sapiens (Human)

Structure

Length:
553
Sequence:
MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPREPKQEDPRVEVTQF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Basolateral cell membrane

Function

Function:
Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.
Gene Ontology Go:
basolateral plasma membrane
integral component of plasma membrane
anion:anion antiporter activity
inorganic anion exchanger activity
short-chain fatty acid uptake transporter activity
sodium-independent organic anion transmembrane transporter activity
anion transmembrane transport
hormone transport
short-chain fatty acid import
sodium-independent organic anion transport
Gene Ontology Biological Process:
anion transmembrane transport
hormone transport
short-chain fatty acid import
sodium-independent organic anion transport
Gene Ontology Molecular Function:
anion:anion antiporter activity
inorganic anion exchanger activity
short-chain fatty acid uptake transporter activity
sodium-independent organic anion transmembrane transporter activity
Gene Ontology Cellular Component:
basolateral plasma membrane
integral component of plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
17393504 14702039 16554811 15489334 11327718 16959974