Names & Taxonomy
- Uniprot ID:
- Q8IVM8
- Entry Name:
- S22A9_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 22 member 9 (Organic anion transporter 7)
- Gene Names:
- SLC22A9 hOAT4 OAT7 UST3
- Gene Names Primary:
- SLC22A9
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 553
- Sequence:
- MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPREPKQEDPRVEVTQF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Basolateral cell membrane
Function
- Function:
- Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes.
- Gene Ontology Go:
- basolateral plasma membrane
integral component of plasma membrane
anion:anion antiporter activity
inorganic anion exchanger activity
short-chain fatty acid uptake transporter activity
sodium-independent organic anion transmembrane transporter activity
anion transmembrane transport
hormone transport
short-chain fatty acid import
sodium-independent organic anion transport - Gene Ontology Biological Process:
- anion transmembrane transport
hormone transport
short-chain fatty acid import
sodium-independent organic anion transport - Gene Ontology Molecular Function:
- anion:anion antiporter activity
inorganic anion exchanger activity
short-chain fatty acid uptake transporter activity
sodium-independent organic anion transmembrane transporter activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
integral component of plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport