Names & Taxonomy
- Uniprot ID:
- Q8IV08
- Entry Name:
- PLD3_HUMAN
- Status:
- reviewed
- Protein Names:
- Phospholipase D3 (PLD 3) (EC 3.1.4.4) (Choline phosphatase 3) (HindIII K4L homolog) (Hu-K4) (Phosphatidylcholine-hydrolyzing phospholipase D3)
- Gene Names:
- PLD3
- Gene Names Primary:
- PLD3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 490
- Sequence:
- MKPKLMYQELKVPAEEPANELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLDFPNASTGNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLRQLQTLAPKGVNVRIAVSKPSGPQPQADLQALLQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRFYDTRYNQETPMEICLNGTPALAYLASAPPPLCPSGRTPDLKALLNVVDNARSFIYVAVMNYLPTLEFSHPHRFWPAIDDGLRRATYERGVKVRLLISCWGHSEPSMRAFLLSLAALRDNHTHSDIQVKLFVVPADEAQARIPYARVNHNKYMVTERATYIGTSNWSGNYFTETAGTSLLVTQNGRGGLRSQLEAIFLRDWDSPYSHDLDTSADSVGNACRLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Probably involved in APP processing.
- Catalytic Activity:
- A phosphatidylcholine + H(2)O = choline + a phosphatidate.
- Active Site:
- ACT_SITE 201 201
- Gene Ontology Go:
- endoplasmic reticulum membrane
extracellular exosome
integral component of membrane
N-acylphosphatidylethanolamine-specific phospholipase D activity
phospholipase D activity
glycerophospholipid biosynthetic process
lipid catabolic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- glycerophospholipid biosynthetic process
lipid catabolic process
phosphatidylglycerol biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- N-acylphosphatidylethanolamine-specific phospholipase D activity
phospholipase D activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
extracellular exosome
integral component of membrane - Keywords:
- Alzheimer disease
Amyloidosis
Complete proteome
Disease mutation
Endoplasmic reticulum
Glycoprotein
Hydrolase
Lipid degradation
Lipid metabolism
Membrane
Neurodegeneration
Reference proteome
Repeat
Signal-anchor
Transmembrane
Transmembrane helix - Interacts With:
- P19838