Names & Taxonomy
- Uniprot ID:
- Q8IUZ5
- Entry Name:
- AT2L2_HUMAN
- Status:
- reviewed
- Protein Names:
- 5-phosphohydroxy-L-lysine phospho-lyase (EC 4.2.3.134) (Alanine--glyoxylate aminotransferase 2-like 2)
- Gene Names:
- PHYKPL AGXT2L2 PP9286
- Gene Names Orf:
- PP9286
- Gene Names Primary:
- PHYKPL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 450
- Sequence:
- MAADQRPKADTLALRQRLISSSCRLFFPEDPVKIVRAQGQYMYDEQGAEYIDCISNVAHVGHCHPLVVQAAHEQNQVLNTNSRYLHDNIVDYAQRLSETLPEQLCVFYFLNSGSEANDLALRLARHYTGHQDVVVLDHAYHGHLSSLIDISPYKFRNLDGQKEWVHVAPLPDTYRGPYREDHPNPAMAYANEVKRVVSSAQEKGRKIAAFFAESLPSVGGQIIPPAGYFSQVAEHIRKAGGVFVADEIQVGFGRVGKHFWAFQLQGKDFVPDIVTMGKSIGNGHPVACVAATQPVARAFEATGVEYFNTFGGSPVSCAVGLAVLNVLEKEQLQDHATSVGSFLMQLLGQQKIKHPIVGDVRGVGLFIGVDLIKDEATRTPATEEAAYLVSRLKENYVLLSTDGPGRNILKFKPPMCFSLDNARQVVAKLDAILTDMEEKVRSCETLRLQP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde.
- Catalytic Activity:
- (5R)-5-phosphonooxy-L-lysine + H(2)O = (S)-2-amino-6-oxohexanoate + NH(3) + phosphate.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=16 uM for 5-phosphohydroxy-L-lysine (at 30 degrees Celsius)
- Cross Reference Drug Bank:
- DB00160
- Gene Ontology Go:
- mitochondrial matrix
identical protein binding
lyase activity
pyridoxal phosphate binding
transaminase activity
cellular nitrogen compound metabolic process
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
lysine catabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
lysine catabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- identical protein binding
lyase activity
pyridoxal phosphate binding
transaminase activity - Gene Ontology Cellular Component:
- mitochondrial matrix
- Keywords:
- Alternative splicing
Aminotransferase
Complete proteome
Disease mutation
Lyase
Mitochondrion
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase - Interacts With:
- Q9NUX5; O60763; Q08AM6