Names & Taxonomy

Uniprot ID:
Q8IUZ5
Entry Name:
AT2L2_HUMAN
Status:
reviewed
Protein Names:
5-phosphohydroxy-L-lysine phospho-lyase (EC 4.2.3.134) (Alanine--glyoxylate aminotransferase 2-like 2)
Gene Names:
PHYKPL AGXT2L2 PP9286
Gene Names Orf:
PP9286
Gene Names Primary:
PHYKPL
Organism:
Homo sapiens (Human)

Structure

Length:
450
Sequence:
MAADQRPKADTLALRQRLISSSCRLFFPEDPVKIVRAQGQYMYDEQGAEYIDCISNVAHVGHCHPLVVQAAHEQNQVLNTNSRYLHDNIVDYAQRLSETLPEQLCVFYFLNSGSEANDLALRLARHYTGHQDVVVLDHAYHGHLSSLIDISPYKFRNLDGQKEWVHVAPLPDTYRGPYREDHPNPAMAYANEVKRVVSSAQEKGRKIAAFFAESLPSVGGQIIPPAGYFSQVAEHIRKAGGVFVADEIQVGFGRVGKHFWAFQLQGKDFVPDIVTMGKSIGNGHPVACVAATQPVARAFEATGVEYFNTFGGSPVSCAVGLAVLNVLEKEQLQDHATSVGSFLMQLLGQQKIKHPIVGDVRGVGLFIGVDLIKDEATRTPATEEAAYLVSRLKENYVLLSTDGPGRNILKFKPPMCFSLDNARQVVAKLDAILTDMEEKVRSCETLRLQP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion

Function

Function:
Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde.
Catalytic Activity:
(5R)-5-phosphonooxy-L-lysine + H(2)O = (S)-2-amino-6-oxohexanoate + NH(3) + phosphate.
Cofactor:
COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=16 uM for 5-phosphohydroxy-L-lysine (at 30 degrees Celsius)
Cross Reference Drug Bank:
DB00160
Gene Ontology Go:
mitochondrial matrix
identical protein binding
lyase activity
pyridoxal phosphate binding
transaminase activity
cellular nitrogen compound metabolic process
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
lysine catabolic process
small molecule metabolic process
Gene Ontology Biological Process:
cellular nitrogen compound metabolic process
collagen catabolic process
extracellular matrix disassembly
extracellular matrix organization
lysine catabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
identical protein binding
lyase activity
pyridoxal phosphate binding
transaminase activity
Gene Ontology Cellular Component:
mitochondrial matrix
Keywords:
Alternative splicing
Aminotransferase
Complete proteome
Disease mutation
Lyase
Mitochondrion
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase
Interacts With:
Q9NUX5; O60763; Q08AM6

Publication

PubMed ID:
15498874 14702039 15372022 15489334 22241472 24275569 23242558