Names & Taxonomy
- Uniprot ID:
- Q86YB8
- Entry Name:
- ERO1B_HUMAN
- Status:
- reviewed
- Protein Names:
- ERO1-like protein beta (ERO1-L-beta) (EC 1.8.4.-) (Endoplasmic reticulum oxidoreductase beta) (Endoplasmic reticulum oxidoreductin-1-like protein B) (Oxidoreductin-1-L-beta)
- Gene Names:
- ERO1B ERO1LB
- Gene Names Primary:
- ERO1B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 467
- Sequence:
- MSQGVRRAGAGQGVAAAVQLLVTLSFLRSVVEAQVTGVLDDCLCDIDSIDNFNTYKIFPKIKKLQERDYFRYYKVNLKRPCPFWAEDGHCSIKDCHVEPCPESKIPVGIKAGHSNKYLKMANNTKELEDCEQANKLGAINSTLSNQSKEAFIDWARYDDSRDHFCELDDERSPAAQYVDLLLNPERYTGYKGTSAWRVWNSIYEENCFKPRSVYRPLNPLAPSRGEDDGESFYTWLEGLCLEKRVFYKLISGLHASINLHLCANYLLEETWGKPSWGPNIKEFKHRFDPVETKGEGPRRLKNLYFLYLIELRALSKVAPYFERSIVDLYTGNAEEDADTKTLLLNIFQDTKSFPMHFDEKSMFAGDKKGAKSLKEEFRLHFKNISRIMDCVGCDKCRLWGKLQTQGLGTALKILFSEKEIQKLPENSPSKGFQLTRQEIVALLNAFGRLSTSIRDLQNFKVLLQHSR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%). Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Enzyme Regulation:
- ENZYME REGULATION: Glutathione may be required to regulate its activity in the endoplasmic reticulum.
- Cross Reference Drug Bank:
- DB03147
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
protein disulfide isomerase activity
protein disulfide oxidoreductase activity
unfolded protein binding
4-hydroxyproline metabolic process
cell redox homeostasis
extracellular matrix organization
glucose homeostasis
insulin processing
protein folding
protein maturation by protein folding - Gene Ontology Biological Process:
- 4-hydroxyproline metabolic process
cell redox homeostasis
extracellular matrix organization
glucose homeostasis
insulin processing
protein folding
protein maturation by protein folding - Gene Ontology Molecular Function:
- oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
protein disulfide isomerase activity
protein disulfide oxidoreductase activity
unfolded protein binding - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane - Keywords:
- Alternative splicing
Complete proteome
Disulfide bond
Electron transport
Endoplasmic reticulum
FAD
Flavoprotein
Glycoprotein
Membrane
Oxidoreductase
Polymorphism
Redox-active center
Reference proteome
Signal
Transport - Interacts With:
- P30101